Detailed information of TA system TA237514

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-rdlD/-
• Location: 4509394..4509663
• Replicon: chromosome
• Accession: NZ_CP093011
• Organism: Escherichia coli strain 131

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: LJF86_RS21800
• Protein ID: WP_001372321.1
• Coordinates: 4509538..4509663 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4509394..4509459 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF86_RS21760	4504469..4504717	+	249	WP_071606928.1	hypothetical protein	-
LJF86_RS21765	4505187..4505714	+	528	WP_241461236.1	single-stranded DNA-binding protein	-
LJF86_RS21770	4505770..4506003	+	234	WP_000006018.1	DUF905 domain-containing protein	-
LJF86_RS21775	4506062..4508020	+	1959	WP_032152921.1	ParB/RepB/Spo0J family partition protein	-
LJF86_RS21780	4508075..4508509	+	435	WP_000845901.1	conjugation system SOS inhibitor PsiB	-
LJF86_RS21785	4508506..4509268	+	763	Protein_4281	plasmid SOS inhibition protein A	-
LJF86_RS21790	4509237..4509425	-	189	WP_001299721.1	hypothetical protein	-
-	4509237..4509461	+	225	NuclAT_0	-	-
-	4509237..4509461	+	225	NuclAT_0	-	-
-	4509237..4509461	+	225	NuclAT_0	-	-
-	4509237..4509461	+	225	NuclAT_0	-	-
-	4509394..4509459	+	66	-	-	Antitoxin
LJF86_RS21795	4509447..4509596	+	150	Protein_4283	plasmid maintenance protein Mok	-
LJF86_RS21800	4509538..4509663	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
LJF86_RS21805	4509883..4510113	+	231	WP_071587244.1	hypothetical protein	-
LJF86_RS21810	4510111..4510284	-	174	Protein_4286	hypothetical protein	-
LJF86_RS21815	4510582..4510869	+	288	WP_000107537.1	hypothetical protein	-
LJF86_RS21820	4510990..4511811	+	822	WP_001234469.1	DUF932 domain-containing protein	-
LJF86_RS21825	4512108..4512755	-	648	WP_124760006.1	transglycosylase SLT domain-containing protein	-
LJF86_RS21830	4513041..4513424	+	384	WP_001151564.1	conjugal transfer relaxosome DNA-binding protein TraM	-
LJF86_RS21835	4513618..4514304	+	687	WP_000332487.1	PAS domain-containing protein	-
LJF86_RS21840	4514398..4514625	+	228	WP_001254388.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	4407369..4577081	169712

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T237514 WP_001372321.1 NZ_CP093011:4509538-4509663 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T237514 NZ_LR882496:2250596-2250994 [Mycobacterium tuberculosis variant microti]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin

Nucleotide

• Length: 66 bp

>AT237514 NZ_CP093011:4509394-4509459 [Escherichia coli]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Structures

Antitoxin