Detailed information of TA system TA237409

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 43082..43346
• Replicon: plasmid pNDM13-SR33
• Accession: NZ_CP092912
• Organism: Salmonella enterica subsp. enterica strain SR33

Toxin (Protein)

• Gene name: pndA
• Uniprot ID: -
• Locus tag: MLD58_RS24300
• Protein ID: WP_193793440.1
• Coordinates: 43194..43346 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	pndB
Locus tag	-
Coordinates	43082..43139 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MLD58_RS24285 (39420)	39420..40490	-	1071	WP_241420308.1	IncI1-type conjugal transfer protein TrbB	-
MLD58_RS24290 (40509)	40509..41717	-	1209	WP_001383960.1	IncI1-type conjugal transfer protein TrbA	-
MLD58_RS24295 (41935)	41935..42888	-	954	WP_021513958.1	hypothetical protein	-
- (43082)	43082..43139	-	58	NuclAT_0	-	Antitoxin
- (43082)	43082..43139	-	58	NuclAT_0	-	Antitoxin
- (43082)	43082..43139	-	58	NuclAT_0	-	Antitoxin
- (43082)	43082..43139	-	58	NuclAT_0	-	Antitoxin
MLD58_RS24300 (43194)	43194..43346	+	153	WP_193793440.1	Hok/Gef family protein	Toxin
MLD58_RS24305 (43418)	43418..43669	-	252	WP_001291964.1	hypothetical protein	-
MLD58_RS24980 (44168)	44168..44263	+	96	WP_001303310.1	DinQ-like type I toxin DqlB	-
MLD58_RS24315 (44328)	44328..44504	-	177	WP_001054900.1	hypothetical protein	-
MLD58_RS24320 (44836)	44836..45045	+	210	WP_000062602.1	HEAT repeat domain-containing protein	-
MLD58_RS24325 (45117)	45117..45779	-	663	WP_193793429.1	plasmid IncI1-type surface exclusion protein ExcA	-
MLD58_RS24330 (45844)	45844..48012	-	2169	WP_000698366.1	DotA/TraY family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	blaNDM-13	-	1..88258	88258

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5745.04 Da
• Isoelectric Point: 8.7948

>T237409 WP_193793440.1 NZ_CP092912:43194-43346 [Salmonella enterica subsp. enterica]
MPQRTFLMMLIVICVTILCFVWTVRDSLCGLRLQQGNTVLVATLAYEVKR

Nucleotide

• Length: 153 bp

>T237409 NZ_LR882052:823804-824211 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT237409 NZ_CP092912:c43139-43082 [Salmonella enterica subsp. enterica]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Antitoxin