Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 833305..833962 Replicon chromosome
Accession NZ_CP092901
Organism Klebsiella pneumoniae strain F11

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag F11wdg_RS04120 Protein ID WP_002916310.1
Coordinates 833552..833962 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag F11wdg_RS04115 Protein ID WP_002916312.1
Coordinates 833305..833571 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F11wdg_RS04090 (828461) 828461..829894 - 1434 WP_064152027.1 6-phospho-beta-glucosidase -
F11wdg_RS04095 (830013) 830013..830741 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
F11wdg_RS04100 (830791) 830791..831102 + 312 WP_064152028.1 N(4)-acetylcytidine aminohydrolase -
F11wdg_RS04105 (831266) 831266..831925 + 660 WP_002916317.1 hemolysin III family protein -
F11wdg_RS04110 (832076) 832076..833059 - 984 WP_064152029.1 tRNA-modifying protein YgfZ -
F11wdg_RS04115 (833305) 833305..833571 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
F11wdg_RS04120 (833552) 833552..833962 + 411 WP_002916310.1 protein YgfX Toxin
F11wdg_RS04125 (833969) 833969..834490 - 522 WP_004144730.1 flavodoxin FldB -
F11wdg_RS04130 (834591) 834591..835487 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
F11wdg_RS04135 (835510) 835510..836223 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
F11wdg_RS04140 (836229) 836229..837962 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T237337 WP_002916310.1 NZ_CP092901:833552-833962 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T237337 NZ_LR881938:c1629902-1629615 [Escherichia coli str. K-12 substr. MG1655]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT237337 WP_002916312.1 NZ_CP092901:833305-833571 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT237337 NZ_LR881938:c1630141-1629902 [Escherichia coli str. K-12 substr. MG1655]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References