Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4384187..4384913 Replicon chromosome
Accession NZ_CP092861
Organism Salmonella enterica strain P164045

Toxin (Protein)


Gene name ykfI Uniprot ID A0A248KBV8
Locus tag MLB75_RS21995 Protein ID WP_001194750.1
Coordinates 4384187..4384528 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A5W8CBX5
Locus tag MLB75_RS22000 Protein ID WP_000380486.1
Coordinates 4384572..4384913 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MLB75_RS21960 (4379202) 4379202..4379747 - 546 WP_000718702.1 hypothetical protein -
MLB75_RS21965 (4379762) 4379762..4380802 - 1041 WP_000617193.1 ParB/Srx family N-terminal domain-containing protein -
MLB75_RS21970 (4380984) 4380984..4381163 - 180 WP_229023603.1 Arm DNA-binding domain-containing protein -
MLB75_RS21975 (4381720) 4381720..4382517 - 798 WP_241065874.1 helix-turn-helix transcriptional regulator -
MLB75_RS21980 (4382634) 4382634..4382909 - 276 WP_000409331.1 type II toxin-antitoxin system RelE/ParE family toxin -
MLB75_RS21985 (4382913) 4382913..4383161 - 249 WP_241065875.1 ribbon-helix-helix domain-containing protein -
MLB75_RS21990 (4383238) 4383238..4384071 - 834 WP_198871409.1 DUF4942 domain-containing protein -
MLB75_RS21995 (4384187) 4384187..4384528 - 342 WP_001194750.1 TA system toxin CbtA family protein Toxin
MLB75_RS22000 (4384572) 4384572..4384913 - 342 WP_000380486.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MLB75_RS22005 (4385016) 4385016..4385843 + 828 WP_223164635.1 5'-nucleotidase -
MLB75_RS22010 (4385921) 4385921..4386796 - 876 WP_000135476.1 HNH endonuclease -
MLB75_RS22015 (4387012) 4387012..4388276 - 1265 Protein_4319 integrase arm-type DNA-binding domain-containing protein -
MLB75_RS22025 (4388770) 4388770..4389789 + 1020 WP_000152563.1 NAD(P)-dependent alcohol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(2-109)

Antitoxin

Antitoxin CbeA

(11-109)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13116.01 Da        Isoelectric Point: 9.7617

>T237314 WP_001194750.1 NZ_CP092861:c4384528-4384187 [Salmonella enterica]
MQTQYNHPHRATPSQPSPVEIWQKLLTHLLAKHYGLELSDTPFSVEKVIQEHIDAGITLANAVNFIVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRRQRYLAAH

Download         Length: 342 bp

>T237314 NZ_LR881934:c5052086-5051712 [Citrobacter freundii]
ATGGTCAAAGGATCCGCGCTTTTTGATACCAACATCCTCATCGATCTGTTTAGTGGGAGAAATGAAGCAAAACTAGCGAT
AGAAACATGGCCGCCGCAGAATGCAATCAGCCTCATTACATGGATGGAGGTGATGGTGGGTGCAAAAAAATACCATCAGG
AAGCCCGTACTCGTGTTGCGCTAGGTGCTTTTAACGTGATCGGCGTTTCACAGGATATTGCTGAACGAAGCGTGAGTATC
AGACAGGAATATGGGATGAAATTGCCGGATGCCATTATTTTGGCAACAGCACAGATTCATCGTCTTACGCTGGTTACGCG
AAATACTAAGGATTTTGCAGGCCTATCCGGTGTGGTCACACCGTATACATTATAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12772.63 Da        Isoelectric Point: 9.4771

>AT237314 WP_000380486.1 NZ_CP092861:c4384913-4384572 [Salmonella enterica]
MDTNETQSTPVWGLRNDVFPSFGARLVQEGNHLHYLADRAGIYGEFTPAQLKTLNILFPMFIKRMEVALRTGALNPREAR
RFTTALRGITCEADTRGSFGYVYLSLYPTVVKN

Download         Length: 342 bp

>AT237314 NZ_LR881934:c5052328-5052086 [Citrobacter freundii]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGATGAAGTGATTAAACGTCTTGATGATCTCAAGGT
GCAGCGCAACCTGCCGCGAGCAGAACTTTTACGGGAGGCCGTTGAACAGTATCTTGAGAGGCAGGATCAGGCTGAAACCA
CAATTTCACGTGCTCTTGGGCTGTGGCAAGGCTGTGAGGAAGATGGTGTTGAATACCAGCGTAAACTCCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248KBV8

Antitoxin

Source ID Structure
AlphaFold DB A0A5W8CBX5

References