Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 885102..885762 Replicon chromosome
Accession NZ_CP092861
Organism Salmonella enterica strain P164045

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag MLB75_RS04360 Protein ID WP_000244756.1
Coordinates 885349..885762 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag MLB75_RS04355 Protein ID WP_000351186.1
Coordinates 885102..885368 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MLB75_RS04335 (881029) 881029..882462 - 1434 WP_001230140.1 6-phospho-beta-glucosidase BglA -
MLB75_RS04340 (882621) 882621..882932 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
MLB75_RS04345 (883097) 883097..883756 + 660 WP_000250289.1 hemolysin III family protein -
MLB75_RS04350 (883872) 883872..884852 - 981 WP_000874170.1 tRNA-modifying protein YgfZ -
MLB75_RS04355 (885102) 885102..885368 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
MLB75_RS04360 (885349) 885349..885762 + 414 WP_000244756.1 protein YgfX Toxin
MLB75_RS04365 (885815) 885815..886336 - 522 WP_001055885.1 flavodoxin FldB -
MLB75_RS04370 (886449) 886449..887345 + 897 WP_061383818.1 site-specific tyrosine recombinase XerD -
MLB75_RS04375 (887369) 887369..888082 + 714 WP_020437840.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MLB75_RS04380 (888088) 888088..889821 + 1734 WP_001522853.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T237300 WP_000244756.1 NZ_CP092861:885349-885762 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T237300 NZ_LR878367:c21203-21054 [Shigella flexneri 3a]
ATGACGAAGTATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT237300 WP_000351186.1 NZ_CP092861:885102-885368 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT237300 NZ_LR878367:21248-21307 [Shigella flexneri 3a]
AATGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTTGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References