Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 389511..390076 Replicon chromosome II
Accession NC_012583
Organism Vibrio cholerae O395

Toxin (Protein)


Gene name relE Uniprot ID D7HCW8
Locus tag VC395_RS16155 Protein ID WP_000869999.1
Coordinates 389789..390076 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D0IIK3
Locus tag VC395_RS16150 Protein ID WP_000086649.1
Coordinates 389511..389792 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VC395_RS20860 384866..384976 + 111 Protein_365 DUF3265 domain-containing protein -
VC395_RS16110 385015..385401 + 387 WP_000703163.1 VOC family protein -
VC395_RS16115 385658..385861 + 204 WP_001911580.1 hypothetical protein -
VC395_RS16120 386056..386307 + 252 WP_001890111.1 TIGR03643 family protein -
VC395_RS20235 386280..386429 + 150 WP_071908333.1 DUF3265 domain-containing protein -
VC395_RS16125 386456..386971 + 516 WP_001201533.1 lipocalin family protein -
VC395_RS16130 387274..387456 + 183 WP_000947513.1 DUF645 family protein -
VC395_RS16135 387665..388123 + 459 WP_000650937.1 hypothetical protein -
VC395_RS16140 388274..388636 + 363 WP_000454151.1 hypothetical protein -
VC395_RS20625 388636..388722 + 87 WP_071917830.1 DUF3265 domain-containing protein -
VC395_RS16145 388872..389297 + 426 WP_000735184.1 hypothetical protein -
VC395_RS16150 389511..389792 + 282 WP_000086649.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VC395_RS16155 389789..390076 + 288 WP_000869999.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VC395_RS16160 390235..390774 + 540 WP_000884561.1 hydrolase -
VC395_RS16165 390909..391358 + 450 WP_000480555.1 hypothetical protein -
VC395_RS16175 391653..391835 + 183 WP_001889223.1 DUF645 family protein -
VC395_RS16180 392043..392735 + 693 WP_000780703.1 hypothetical protein -
VC395_RS16185 392735..393295 + 561 Protein_382 hypothetical protein -
VC395_RS16190 393410..393820 + 411 WP_000452031.1 hypothetical protein -
VC395_RS16195 393915..394340 + 426 WP_000403003.1 GNAT family N-acetyltransferase -
VC395_RS16200 394584..394820 + 237 WP_001065132.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 344619..430484 85865


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10997.74 Da        Isoelectric Point: 6.0710

>T23729 WP_000869999.1 NC_012583:389789-390076 [Vibrio cholerae O395]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV

Download         Length: 288 bp

>T23729 NC_012583:389789-390076 [Vibrio cholerae O395]
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTGGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGGTCATTACCGCATTATTTATAGTTTGAGCCACGAAATCCGCGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10361.93 Da        Isoelectric Point: 5.1548

>AT23729 WP_000086649.1 NC_012583:389511-389792 [Vibrio cholerae O395]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK

Download         Length: 282 bp

>AT23729 NC_012583:389511-389792 [Vibrio cholerae O395]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGACCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGCATCATCAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3AEF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9UIW4

References