Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 830237..830751 Replicon chromosome
Accession NZ_CP092857
Organism Staphylococcus capitis strain LR 95

Toxin (Protein)


Gene name TsdT Uniprot ID A0A1J4E3P3
Locus tag MMG96_RS03955 Protein ID WP_023351364.1
Coordinates 830545..830751 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A1J4E888
Locus tag MMG96_RS03950 Protein ID WP_002435858.1
Coordinates 830237..830530 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMG96_RS03925 (MMG96_03925) 825395..826183 + 789 WP_023351361.1 hydroxyethylthiazole kinase -
MMG96_RS03930 (MMG96_03930) 826190..826828 + 639 WP_023351362.1 thiamine phosphate synthase -
MMG96_RS03935 (MMG96_03935) 826917..827789 + 873 WP_002435877.1 membrane protein insertase YidC -
MMG96_RS03940 (MMG96_03940) 827848..828510 - 663 WP_023351363.1 HD domain-containing protein -
MMG96_RS03945 (MMG96_03945) 828567..830051 - 1485 WP_002435854.1 cardiolipin synthase -
MMG96_RS03950 (MMG96_03950) 830237..830530 + 294 WP_002435858.1 copper-sensing transcriptional repressor CsoR Antitoxin
MMG96_RS03955 (MMG96_03955) 830545..830751 + 207 WP_023351364.1 hypothetical protein Toxin
MMG96_RS03960 (MMG96_03960) 830888..831025 + 138 WP_002435861.1 Lmo0850 family protein -
MMG96_RS03965 (MMG96_03965) 831081..832292 - 1212 WP_023351365.1 FtsW/RodA/SpoVE family cell cycle protein -
MMG96_RS03970 (MMG96_03970) 832697..833767 + 1071 WP_002435813.1 D-alanine--D-alanine ligase -
MMG96_RS03975 (MMG96_03975) 833783..835138 + 1356 WP_023351368.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7821.85 Da        Isoelectric Point: 4.2087

>T237275 WP_023351364.1 NZ_CP092857:830545-830751 [Staphylococcus capitis]
MENGIVYVANIETIEEENQLKTRLENMIGVEKVDIDSKVGEIKVLFETPANLNSIEKEVYDSGFRVRY

Download         Length: 207 bp

>T237275 NZ_LR861805:c4480959-4480807 [Xanthomonas sp. CPBF 426]
ATGAAGCGACTGCTGACACTGATGGTACTGGGCCTGTTTTCGGCCGGCGTGATGACTGGCTGCAACACCATGGCTGGCGC
CGGCAAGGACATGCAGGGCGCGGGCGAGAAGGTCGAGAAGAAGGCCGACAATTGCAGTGACGGTAAGTGCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11065.56 Da        Isoelectric Point: 6.4776

>AT237275 WP_002435858.1 NZ_CP092857:830237-830530 [Staphylococcus capitis]
VTENETAHHSEQTKANLKSRLNRIEGQVRAINRMIEDDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMNKVNNGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT237275 NZ_LR861805:c4480728-4480594 [Xanthomonas sp. CPBF 426]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGGTGTTGTCGGTCGGTATGCTGTCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCCGGCGAGAAGGTGGAAGACGCTGCGCGCAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J4E3P3

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4E888

References