Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 407050..407609 Replicon chromosome II
Accession NC_012580
Organism Vibrio cholerae M66-2

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag VCM66_RS15435 Protein ID WP_000578476.1
Coordinates 407050..407328 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag VCM66_RS15440 Protein ID WP_000381183.1
Coordinates 407325..407609 (-) Length 95 a.a.

Genomic Context

VCM66_RS15400VCM66_RS15405VCM66_RS15410VCM66_RS15415VCM66_RS19440VCM66_RS15420VCM66_RS15425VCM66_RS19445VCM66_RS15430VCM66_RS15445VCM66_RS15450VCM66_RS15460VCM66_RS15435VCM66_RS15440
Location: 402350..402787 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 402851..403069 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 403244..404116 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 404266..404865 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 404922..405026 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 405057..405326 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 405320..405841 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 406140..406265 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 406516..406911 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 407803..408318 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 408502..408915 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 409470..410647 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 407050..407328 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 407325..407609 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCM66_RS15400402350..402787+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
VCM66_RS15405402851..403069+219WP_071908318.1GNAT family N-acetyltransferase-
VCM66_RS15410403244..404116+873WP_000254716.1DUF3800 domain-containing protein-
VCM66_RS15415404266..404865+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
VCM66_RS19440404922..405026+105WP_099607150.1acetyltransferase-
VCM66_RS15420405057..405326+270WP_001114075.1DUF4160 domain-containing protein-
VCM66_RS15425405320..405841+522WP_000921691.1DUF2442 domain-containing protein-
VCM66_RS19445406140..406265+126WP_001905700.1DUF645 family protein-
VCM66_RS15430406516..406911+396WP_001000867.1hypothetical protein-
VCM66_RS15435407050..407328-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
VCM66_RS15440407325..407609-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
VCM66_RS15445407803..408318+516WP_000343779.1GNAT family N-acetyltransferase-
VCM66_RS15450408502..408915+414WP_000049420.1VOC family protein-
VCM66_RS15460409470..410647+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--305869..409778103909
-insideIntegron--310949..40940298453
flankIS/Tn--402350..402787437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T23721 WP_000578476.1 NC_012580:c407328-407050 [Vibrio cholerae M66-2]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T23721 NC_012580:c407328-407050 [Vibrio cholerae M66-2]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT23721 WP_000381183.1 NC_012580:c407609-407325 [Vibrio cholerae M66-2]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT23721 NC_012580:c407609-407325 [Vibrio cholerae M66-2]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References