Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 84093..85003 | Replicon | plasmid pXH1507-1 |
| Accession | NZ_CP092794 | ||
| Organism | Klebsiella pneumoniae strain XH1507 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | ML258_RS27500 | Protein ID | WP_004026354.1 |
| Coordinates | 84093..84563 (-) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6P1V3Q9 |
| Locus tag | ML258_RS27505 | Protein ID | WP_004026357.1 |
| Coordinates | 84560..85003 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ML258_RS27460 (ML258_27460) | 79409..79723 | + | 315 | WP_011251273.1 | hypothetical protein | - |
| ML258_RS27465 (ML258_27465) | 79732..80226 | + | 495 | WP_011251274.1 | hypothetical protein | - |
| ML258_RS27470 (ML258_27470) | 80232..80672 | + | 441 | WP_011251275.1 | hypothetical protein | - |
| ML258_RS27475 (ML258_27475) | 81097..82053 | - | 957 | WP_011251280.1 | DsbA family protein | - |
| ML258_RS27480 (ML258_27480) | 82113..82454 | - | 342 | WP_011251281.1 | hypothetical protein | - |
| ML258_RS27485 (ML258_27485) | 82468..82779 | - | 312 | WP_011251282.1 | hypothetical protein | - |
| ML258_RS27490 (ML258_27490) | 82796..83245 | - | 450 | WP_011251283.1 | thioredoxin fold domain-containing protein | - |
| ML258_RS27500 (ML258_27500) | 84093..84563 | - | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| ML258_RS27505 (ML258_27505) | 84560..85003 | - | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
| ML258_RS27510 (ML258_27510) | 85104..85607 | - | 504 | Protein_97 | DUF4113 domain-containing protein | - |
| ML258_RS27515 (ML258_27515) | 85813..86793 | - | 981 | WP_000019473.1 | IS5-like element ISKpn26 family transposase | - |
| ML258_RS27520 (ML258_27520) | 86859..88166 | + | 1308 | Protein_99 | FepA family TonB-dependent siderophore receptor | - |
| ML258_RS27525 (ML258_27525) | 88228..88449 | + | 222 | WP_004213615.1 | hypothetical protein | - |
| ML258_RS27530 (ML258_27530) | 88592..89494 | - | 903 | WP_004213613.1 | DMT family inner membrane transporter PEG344 | - |
| ML258_RS27535 (ML258_27535) | 89567..89968 | - | 402 | WP_214588034.1 | LuxR C-terminal-related transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 | 1..198615 | 198615 | |
| - | inside | IScluster/Tn | - | iroN / rmpA | 77812..97788 | 19976 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T237192 WP_004026354.1 NZ_CP092794:c84563-84093 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
>T237192 NZ_LR782232:c4432867-4432517 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT237192 WP_004026357.1 NZ_CP092794:c85003-84560 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
>AT237192 NZ_LR782232:c4433112-4432861 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AYG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V3Q9 |