Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2680155..2681743 Replicon chromosome
Accession NZ_CP092759
Organism Klebsiella pneumoniae strain bat16

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag MKZ45_RS13335 Protein ID WP_002904792.1
Coordinates 2680155..2681477 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag MKZ45_RS13340 Protein ID WP_002904790.1
Coordinates 2681477..2681743 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKZ45_RS13320 (MKZ45_13320) 2675211..2677712 + 2502 WP_004151634.1 fimbria/pilus outer membrane usher protein -
MKZ45_RS13325 (MKZ45_13325) 2677700..2678704 + 1005 WP_002904798.1 fimbrial protein -
MKZ45_RS13330 (MKZ45_13330) 2678846..2680138 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
MKZ45_RS13335 (MKZ45_13335) 2680155..2681477 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
MKZ45_RS13340 (MKZ45_13340) 2681477..2681743 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
MKZ45_RS13345 (MKZ45_13345) 2682009..2682335 - 327 WP_002904788.1 hydroxyisourate hydrolase -
MKZ45_RS13350 (MKZ45_13350) 2682332..2682832 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
MKZ45_RS13355 (MKZ45_13355) 2682810..2684189 - 1380 WP_002904785.1 nucleobase:cation symporter-2 family protein -
MKZ45_RS13360 (MKZ45_13360) 2684535..2685689 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
MKZ45_RS13365 (MKZ45_13365) 2685670..2686593 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T237099 WP_002904792.1 NZ_CP092759:c2681477-2680155 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T237099 NZ_LR778150:2782310-2782417 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT237099 WP_002904790.1 NZ_CP092759:c2681743-2681477 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT237099 NZ_LR778150:c2782257-2782196 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References