Detailed information of TA system TA236956

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3625432..3625852
• Replicon: chromosome
• Accession: NZ_CP092690
• Organism: Salmonella enterica subsp. enterica serovar Thompson strain MFDS1011716

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A8E7RAJ3
• Locus tag: MKV11_RS17875
• Protein ID: WP_000994215.1
• Coordinates: 3625589..3625852 (+)
• Length: 88 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3625432..3625842 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKV11_RS17835	3620725..3621465	-	741	WP_017465813.1	pili assembly chaperone SafB	-
MKV11_RS17840	3621540..3622037	-	498	WP_017465814.1	hypothetical protein	-
MKV11_RS17845	3622170..3622664	-	495	WP_017465815.1	hypothetical protein	-
MKV11_RS17850	3623459..3624160	-	702	Protein_3494	integrase core domain-containing protein	-
MKV11_RS17855	3624213..3624386	+	174	WP_001531381.1	hypothetical protein	-
MKV11_RS17860	3624451..3624918	-	468	WP_001284951.1	Imm42 family immunity protein	-
MKV11_RS17865	3624911..3625219	-	309	WP_166427842.1	hypothetical protein	-
MKV11_RS17870	3625210..3625347	-	138	WP_231391191.1	hypothetical protein	-
-	3625432..3625842	-	411	-	-	Antitoxin
MKV11_RS17875	3625589..3625852	+	264	WP_000994215.1	hypothetical protein	Toxin
MKV11_RS17880	3625899..3626333	-	435	WP_000789494.1	hypothetical protein	-
MKV11_RS17885	3626330..3627634	-	1305	Protein_3501	RHS repeat-associated core domain-containing protein	-
MKV11_RS17890	3627771..3628235	-	465	WP_223227916.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3613650..3657023	43373

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9458.71 Da
• Isoelectric Point: 6.4458

>T236956 WP_000994215.1 NZ_CP092690:3625589-3625852 [Salmonella enterica subsp. enterica serovar Thompson]
MNASGASVRHINSETCMTTCYSQIPSGDCQEEAGFETGASVVVKISERGLILIAETDEVRDLRKELYQVKKSMKHIKAGV
NNVVNGN

Nucleotide

• Length: 264 bp

>T236956 NZ_LR778142:201275-201448 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Nucleotide

• Length: 411 bp

>AT236956 NZ_CP092690:c3625842-3625432 [Salmonella enterica subsp. enterica serovar Thompson]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCATCCGTTTCTGCAATCAGGATCAAACCCCGCTCGGAGATCTTCACAACAACGCTCGCCCCGGTCTCAAATCCCGCTT
CTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCG
CCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAG
CGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCCGG
GGCCGTATTTT

Structures

Antitoxin