Detailed information of TA system TA236889

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4558073..4558856
• Replicon: chromosome
• Accession: NZ_CP092648
• Organism: Klebsiella pneumoniae strain KP7728

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: MJ615_RS22255
• Protein ID: WP_069734344.1
• Coordinates: 4558073..4558447 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: MJ615_RS22260
• Protein ID: WP_069734343.1
• Coordinates: 4558497..4558856 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJ615_RS22240 (4554409)	4554409..4554843	+	435	WP_069734348.1	antiviral protein Drt1b	-
MJ615_RS22245 (4555144)	4555144..4555941	-	798	WP_117088841.1	helix-turn-helix transcriptional regulator	-
MJ615_RS22250 (4556545)	4556545..4557534	+	990	WP_069734346.1	glycosyltransferase	-
MJ615_RS22255 (4558073)	4558073..4558447	-	375	WP_069734344.1	TA system toxin CbtA family protein	Toxin
MJ615_RS22260 (4558497)	4558497..4558856	-	360	WP_069734343.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
MJ615_RS22265 (4558879)	4558879..4559100	-	222	WP_069734358.1	DUF987 domain-containing protein	-
MJ615_RS22270 (4559114)	4559114..4559596	-	483	WP_069734342.1	DNA repair protein RadC	-
MJ615_RS22275 (4559837)	4559837..4560316	-	480	WP_069734341.1	antirestriction protein	-
MJ615_RS22280 (4560396)	4560396..4561217	-	822	WP_069734340.1	DUF932 domain-containing protein	-
MJ615_RS22285 (4561328)	4561328..4561540	-	213	WP_010434180.1	hypothetical protein	-
MJ615_RS22290 (4561621)	4561621..4561980	-	360	WP_069734339.1	hypothetical protein	-
MJ615_RS22295 (4562035)	4562035..4562445	-	411	WP_069734357.1	hypothetical protein	-
MJ615_RS22300 (4562553)	4562553..4563230	-	678	WP_069734338.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4554631..4573379	18748

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (8-112)

Antitoxin

• Antitoxin CbeA (15-114)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13963.97 Da
• Isoelectric Point: 10.1569

>T236889 WP_069734344.1 NZ_CP092648:c4558447-4558073 [Klebsiella pneumoniae]
MQKQSLSSHRAASSRLSSIEIWRKLLKYLLEQHYGLTLNDTPFGNDSVIQKHIDAGISLCDAVNFIVEKYDLVRTDRHGF
SVKEQSPFIGSIDMLRARKATGLMTRKGYKTVTDITGDRFSGGK

Nucleotide

• Length: 375 bp

>T236889 NZ_LR745043:18936-19379 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13362.56 Da
• Isoelectric Point: 8.5076

>AT236889 WP_069734343.1 NZ_CP092648:c4558856-4558497 [Klebsiella pneumoniae]
MKKATRVINHNIAEPWWGLRRNITPCLGARLVQEGNRLHYLADRASIAGTFNDADLRHLDQAFPVLMKQMELMLASRELT
PHIQRCITLHAKGLICEADTLGSCGYLYIVIYPTSATTA

Nucleotide

• Length: 360 bp

>AT236889 NZ_LR745043:18709-18939 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA