Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4130444..4131248 Replicon chromosome
Accession NZ_CP092648
Organism Klebsiella pneumoniae strain KP7728

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag MJ615_RS20125 Protein ID WP_047683725.1
Coordinates 4130444..4130833 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag MJ615_RS20130 Protein ID WP_047683727.1
Coordinates 4130889..4131248 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ615_RS20105 (4127192) 4127192..4128730 - 1539 WP_004181747.1 IS66 family transposase -
MJ615_RS20110 (4128780) 4128780..4129127 - 348 WP_004114612.1 IS66 family insertion sequence element accessory protein TnpB -
MJ615_RS20115 (4129124) 4129124..4129501 - 378 WP_023280007.1 transposase -
MJ615_RS20120 (4129577) 4129577..4130362 - 786 WP_240289419.1 DUF4942 domain-containing protein -
MJ615_RS20125 (4130444) 4130444..4130833 - 390 WP_047683725.1 TA system toxin CbtA family protein Toxin
MJ615_RS20130 (4130889) 4130889..4131248 - 360 WP_047683727.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MJ615_RS20135 (4131273) 4131273..4131494 - 222 WP_014837279.1 DUF987 domain-containing protein -
MJ615_RS20140 (4131508) 4131508..4131987 - 480 WP_014837278.1 DNA repair protein RadC -
MJ615_RS20145 (4131999) 4131999..4132442 - 444 WP_014837277.1 antirestriction protein -
MJ615_RS20150 (4132522) 4132522..4132752 - 231 WP_014837276.1 DUF905 domain-containing protein -
MJ615_RS20155 (4132776) 4132776..4133600 - 825 WP_040217125.1 DUF932 domain-containing protein -
MJ615_RS20160 (4134142) 4134142..4134774 + 633 WP_072040125.1 inovirus Gp2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(3-110)

Antitoxin

Antitoxin CbeA

(16-114)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14426.58 Da        Isoelectric Point: 9.1379

>T236886 WP_047683725.1 NZ_CP092648:c4130833-4130444 [Klebsiella pneumoniae]
MQTKSPPFMRAASSRPSPVGVWQTLLTCLLEHHYGLTLNDTPFSDELVIQQHIEAGISLADALNFIVEKYELVRTDRPGF
SIREQSPFITSIDILRARKATGLMNCGTYKDVTAITRGLHRQVSTPGKR

Download         Length: 390 bp

>T236886 NZ_LR745042:c4690790-4690506 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13474.28 Da        Isoelectric Point: 6.7394

>AT236886 WP_047683727.1 NZ_CP092648:c4131248-4130889 [Klebsiella pneumoniae]
MSKKTTIETHDISESWWGLRRSVSACFGARLVQEGNRLHYLADRANFNGQFCDADLRHLDQSFPVLMKQLELMLTSGELN
PRHQHCVTLYAKGLTCEADTLGSHGYVYIAIYPTPVTTE

Download         Length: 360 bp

>AT236886 NZ_LR745042:c4691022-4690780 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References