Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 481772..483378 Replicon chromosome
Accession NZ_CP092630
Organism Shewanella xiamenensis strain CQ-Y1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag MKD32_RS02220 Protein ID WP_240292877.1
Coordinates 482050..483378 (+) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag MKD32_RS02215 Protein ID WP_208660398.1
Coordinates 481772..482050 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKD32_RS02190 (MKD32_02190) 477421..478320 + 900 WP_181382104.1 tyrosine recombinase XerC -
MKD32_RS02195 (MKD32_02195) 478320..479042 + 723 WP_240292875.1 HAD-IA family hydrolase -
MKD32_RS02200 (MKD32_02200) 479157..479735 + 579 WP_144346649.1 HupE/UreJ family protein -
MKD32_RS02205 (MKD32_02205) 479744..480247 - 504 WP_047537623.1 ATP-binding protein -
MKD32_RS02210 (MKD32_02210) 480346..481092 - 747 WP_240292876.1 iron-sulfur cluster repair di-iron protein -
MKD32_RS02215 (MKD32_02215) 481772..482050 + 279 WP_208660398.1 helix-turn-helix domain-containing protein Antitoxin
MKD32_RS02220 (MKD32_02220) 482050..483378 + 1329 WP_240292877.1 type II toxin-antitoxin system HipA family toxin Toxin
MKD32_RS02225 (MKD32_02225) 483823..484662 + 840 WP_240292878.1 hypothetical protein -
MKD32_RS02230 (MKD32_02230) 484770..484994 + 225 WP_240292879.1 AlpA family phage regulatory protein -
MKD32_RS02235 (MKD32_02235) 485408..486304 + 897 WP_240292880.1 inovirus-type Gp2 protein -
MKD32_RS02240 (MKD32_02240) 486301..487002 + 702 WP_240292881.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 49047.03 Da        Isoelectric Point: 7.1957

>T236762 WP_240292877.1 NZ_CP092630:482050-483378 [Shewanella xiamenensis]
MAALDVYMNGYLVGEFIKTPTGAHQFKYHEDWLALAGSRPISLSMPLRRQAYIGDEVYNFFDNLLPDNPEVRNRIVARHQ
AASSQPFDLLAKIGQDSVGALQLIPQGELPINVRQIDAKPLSSAELEKVLKGYLSGIPLGMLREQDDFRISIAGAQEKTA
LLNIDGKWCLPLHATPTTHIIKLPIGTIKGHSFDIDMSDSVENEYLCMKIAKAFGLAVAGCNIMKVGDIKALVVERFDRR
LASDGSWLMRLPQEDFCQVLNVPPAKKYESDGGPGIQEIMAQLLGSAMPERDRHDFMKAQVLFWLLGAIDGHAKNFSIFI
DAGGGYRLTPLYDILSIYPALGGKGPNIRDVKLAMALKGSKGKKVLLESIFPRHFILTAKTVGFDTDSMVGIMTEMADML
DFVIMKVSRELPDDFPVQIRDSIINGLKKRAQRLSIENLTRF

Download         Length: 1329 bp

>T236762 NZ_LR738720:572460-572720 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10469.90 Da        Isoelectric Point: 9.6559

>AT236762 WP_208660398.1 NZ_CP092630:481772-482050 [Shewanella xiamenensis]
MKVTTAKQLSNYLKDTRLSLKLSQSKVANKVGIRQDTVSSFEQNPDSTKLETLFKLLASLNLELEVKKRGASIDNIRLDN
TSLDGQDWKEEW

Download         Length: 279 bp

>AT236762 NZ_LR738720:572237-572458 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGATAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References