Detailed information of TA system TA023660

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1179660..1180158
• Replicon: chromosome
• Accession: NC_012467
• Organism: Streptococcus pneumoniae P1031

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C1CEI0
• Locus tag: SPP_RS06240
• Protein ID: WP_001823540.1
• Coordinates: 1179660..1179914 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SPP_RS06245
• Protein ID: WP_012677101.1
• Coordinates: 1179916..1180158 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPP_RS06225	1174932..1177400	-	2469	WP_001152988.1	DNA gyrase subunit A	-
SPP_RS06230	1177594..1178580	+	987	WP_000204727.1	L-lactate dehydrogenase	-
SPP_RS06235	1178870..1179613	-	744	WP_000725952.1	ion transporter	-
SPP_RS06240	1179660..1179914	-	255	WP_001823540.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SPP_RS06245	1179916..1180158	-	243	WP_012677101.1	hypothetical protein	Antitoxin
SPP_RS06250	1180249..1181058	-	810	WP_001289496.1	MBL fold metallo-hydrolase	-
SPP_RS06255	1181060..1182409	-	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
SPP_RS06260	1182402..1183106	-	705	WP_000722076.1	response regulator transcription factor	-
SPP_RS06265	1183162..1184337	-	1176	WP_000886147.1	A/G-specific adenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10040.76 Da
• Isoelectric Point: 10.9371

>T23660 WP_001823540.1 NC_012467:c1179914-1179660 [Streptococcus pneumoniae P1031]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEGPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T23660 NC_012467:c1179914-1179660 [Streptococcus pneumoniae P1031]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGGCCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9204.47 Da
• Isoelectric Point: 4.1051

>AT23660 WP_012677101.1 NC_012467:c1180158-1179916 [Streptococcus pneumoniae P1031]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVANLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT23660 NC_012467:c1180158-1179916 [Streptococcus pneumoniae P1031]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAAATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Structures

Toxin

• AlphaFold DB: C1CEI0