Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4406194..4407026 Replicon chromosome
Accession NZ_CP092534
Organism Escherichia coli strain DS566

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag MKD44_RS21510 Protein ID WP_000854753.1
Coordinates 4406652..4407026 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NQ68
Locus tag MKD44_RS21505 Protein ID WP_001540478.1
Coordinates 4406194..4406562 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKD44_RS21470 (4402027) 4402027..4402707 + 681 WP_001282919.1 WYL domain-containing protein -
MKD44_RS21475 (4402855) 4402855..4403532 + 678 WP_001097301.1 hypothetical protein -
MKD44_RS21480 (4403538) 4403538..4403771 + 234 WP_001278283.1 DUF905 family protein -
MKD44_RS21485 (4403861) 4403861..4404679 + 819 WP_001773857.1 DUF932 domain-containing protein -
MKD44_RS21490 (4404770) 4404770..4405255 + 486 WP_000214398.1 antirestriction protein -
MKD44_RS21495 (4405271) 4405271..4405747 + 477 WP_001186786.1 RadC family protein -
MKD44_RS21500 (4405810) 4405810..4406031 + 222 WP_000692311.1 DUF987 domain-containing protein -
MKD44_RS21505 (4406194) 4406194..4406562 + 369 WP_001540478.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MKD44_RS21510 (4406652) 4406652..4407026 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
MKD44_RS21515 (4407023) 4407023..4407511 + 489 WP_000777545.1 DUF5983 family protein -
MKD44_RS21520 (4407523) 4407523..4407720 + 198 WP_000839281.1 DUF957 domain-containing protein -
MKD44_RS21525 (4407817) 4407817..4408386 + 570 WP_001560692.1 DUF4942 domain-containing protein -
MKD44_RS21530 (4409135) 4409135..4410673 + 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4362090..4418486 56396


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T236450 WP_000854753.1 NZ_CP092534:4406652-4407026 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T236450 NZ_LR594050:c643763-642918 [Streptococcus porcinus]
ATGAATAAAGCTAAGCTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGATTAACCTTTAATTCCGTGATGACCTA
TTACTTTCTTGAAGTGATTTTGAAAAAATTAAGTCAGAGTACCTATTCAAATCACTATATATTCAAAGGAGGATTCCTAC
TGTCAAATGTTATCGGAGTTGAATCTCGTAGCACGGTTGATATTGATTTTTTGTTCCATCAAATAACACTCTCAGAAGAT
ACTGTGAAGCAGCAACTCAAGGAAATTTTAGCAGATTCCGAAGAAGGTATATCTTTTGTGATTCAATCAATCACAGCTAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACAATTTCGTGCCAACTTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGTGATGTTGTAACTCCTCAGCCGATTACATACGACTATAAAGCTATTTTTGATGAAGACAATTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAAAAACTTCAAACCATCTATTCACGTAACTTCTTGAACAGTAGAAG
CAAAGATTTTTACGATGTTTATATTCTTTCAAAACTGAAGAAAGAAGACATTGACTTCATTCAGTTGAGAAATGCCTGTC
AGAGAACATTTTCATATCGCGAAACAGAACTCGATTTTGTAAAGATTATTGAACTACTCGAGAGGTTCAAATCTGACCCT
ATTCAGAATAAACAATGGCAAAATTATTCAAAAAAATATAGCTATACAAAAGGGATTTCACTTGCAGATGTTCTTGATGA
GATGATTCGTCTCATAACAGTTCTCGTTTCTATAAATTCTGATTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13652.53 Da        Isoelectric Point: 7.8398

>AT236450 WP_001540478.1 NZ_CP092534:4406194-4406562 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT236450 NZ_LR594050:c644350-643760 [Streptococcus porcinus]
ATGTCAAAAAAAGAGATTCTACTCGATTTTATAGAAAAGAACAATGGCATTGTCACAAACAAAGATTGTAAAGCACTAGG
TATTCCAACAATATATCTGACAAGACTAGAGAAAGAAGGCATTATCTTCCGAGTTGAAAAAGGTATTTTCCTAACCCAAA
ACGGAGACTATGATGAATACTACTTCTTTCAGTACCGTTATCCCAAGGCTATTTTCTCTTATATCTCAGCGCTTTACCTG
CAACAATTTACAGATGAAATTCCTCAATATTTTGACGTAACCATTCCTAGAGGCTACCGTTTTAATACTCCTCCAGCAAA
TCTGAACATTCATTCCGTTTCTAAGGAATATAGCGAACTAGGAATTACACTTGTAAAAACCCCTATGGGAAACGAGGTAA
GAGTGTATGATTTAGAACGTATTATCTGTGATTTTGTGATTCATCGAGAAAAAATAGATACTGAGCTTTTTGTCAAAACA
CTTCAACATTACGGAAACTATTCTAAAAAAAATCTTACAAAACTCTATGAATATGCGACAAAAATGAACACCTTGGACAA
GGTCAAACAAACTCTGGAGGTCCTAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB S1NQ68

References