Detailed information of TA system TA236345

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3625234..3625654
• Replicon: chromosome
• Accession: NZ_CP092510
• Organism: Salmonella enterica subsp. enterica serovar Thompson

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A8E7RAJ3
• Locus tag: MKE90_RS17865
• Protein ID: WP_000994215.1
• Coordinates: 3625391..3625654 (+)
• Length: 88 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3625234..3625644 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKE90_RS17825	3620527..3621267	-	741	WP_017465813.1	pili assembly chaperone SafB	-
MKE90_RS17830	3621342..3621839	-	498	WP_017465814.1	hypothetical protein	-
MKE90_RS17835	3621972..3622466	-	495	WP_017465815.1	hypothetical protein	-
MKE90_RS17840	3623261..3623962	-	702	Protein_3493	integrase core domain-containing protein	-
MKE90_RS17845	3624015..3624188	+	174	WP_001531381.1	hypothetical protein	-
MKE90_RS17850	3624253..3624720	-	468	WP_001284951.1	Imm42 family immunity protein	-
MKE90_RS17855	3624713..3625021	-	309	WP_166427842.1	hypothetical protein	-
MKE90_RS17860	3625012..3625149	-	138	WP_231391191.1	hypothetical protein	-
-	3625234..3625644	-	411	-	-	Antitoxin
MKE90_RS17865	3625391..3625654	+	264	WP_000994215.1	hypothetical protein	Toxin
MKE90_RS17870	3625701..3626135	-	435	WP_000789494.1	hypothetical protein	-
MKE90_RS17875	3626132..3627436	-	1305	Protein_3500	RHS repeat-associated core domain-containing protein	-
MKE90_RS17880	3627573..3628037	-	465	WP_223227916.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3613452..3656825	43373

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9458.71 Da
• Isoelectric Point: 6.4458

>T236345 WP_000994215.1 NZ_CP092510:3625391-3625654 [Salmonella enterica subsp. enterica serovar Thompson]
MNASGASVRHINSETCMTTCYSQIPSGDCQEEAGFETGASVVVKISERGLILIAETDEVRDLRKELYQVKKSMKHIKAGV
NNVVNGN

Nucleotide

• Length: 264 bp

>T236345 NZ_LR536843:940027-940788 [Streptococcus pneumoniae]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAACAACCTATAGCGATTTTGCTTGGAGGTCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTAGAATATACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGAGATACAATCTTTTGATCGAGGGAACTTTACGAACAGTTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTGGCCTTAATTGCGACAAAGCCTGAATTGTCGTATCTAAGTACTCTTATCCGTTATGAAGAA
CTGTACATTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTAGCTATTTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGATGTTCTTCAAGAGTTACTGTTTGGGGAGTGGAGTCAGGTAGAGAAGGAGATGTTG
CAGGTGGGGGAAAAGAGACTTAATGAATTACTTGAAAAATAA

Antitoxin

Nucleotide

• Length: 411 bp

>AT236345 NZ_CP092510:c3625644-3625234 [Salmonella enterica subsp. enterica serovar Thompson]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCATCCGTTTCTGCAATCAGGATCAAACCCCGCTCGGAGATCTTCACAACAACGCTCGCCCCGGTCTCAAATCCCGCTT
CTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCG
CCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAG
CGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCCGG
GGCCGTATTTT

Structures

Antitoxin