Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeV-yafW/CbtA-CbeA |
| Location | 4593465..4594258 | Replicon | chromosome |
| Accession | NZ_CP092493 | ||
| Organism | Citrobacter freundii strain SCLZS47 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1EZ92 |
| Locus tag | MJ253_RS22770 | Protein ID | WP_000854726.1 |
| Coordinates | 4593881..4594258 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yafW | Uniprot ID | S1EBQ7 |
| Locus tag | MJ253_RS22765 | Protein ID | WP_001548930.1 |
| Coordinates | 4593465..4593791 (+) | Length | 109 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MJ253_RS22720 (4588769) | 4588769..4589590 | + | 822 | WP_008324532.1 | DUF932 domain-containing protein | - |
| MJ253_RS22725 (4589808) | 4589808..4590509 | + | 702 | WP_008324530.1 | WYL domain-containing protein | - |
| MJ253_RS22730 (4590556) | 4590556..4590792 | + | 237 | WP_001115854.1 | protein YpjK | - |
| MJ253_RS22735 (4590792) | 4590792..4591235 | + | 444 | WP_053263801.1 | lipoprotein YafY | - |
| MJ253_RS22740 (4591258) | 4591258..4591725 | + | 468 | WP_001547765.1 | protein YkfB | - |
| MJ253_RS22745 (4591802) | 4591802..4592056 | + | 255 | WP_101743273.1 | DUF905 domain-containing protein | - |
| MJ253_RS27165 (4592070) | 4592070..4592168 | + | 99 | WP_232051968.1 | DUF905 family protein | - |
| MJ253_RS22750 (4592266) | 4592266..4592724 | + | 459 | WP_000211838.1 | antirestriction protein | - |
| MJ253_RS22755 (4592740) | 4592740..4593216 | + | 477 | WP_016243826.1 | RadC family protein | - |
| MJ253_RS22760 (4593225) | 4593225..4593446 | + | 222 | WP_016239820.1 | DUF987 domain-containing protein | - |
| MJ253_RS22765 (4593465) | 4593465..4593791 | + | 327 | WP_001548930.1 | type IV toxin-antitoxin system antitoxin YafW | Antitoxin |
| MJ253_RS22770 (4593881) | 4593881..4594258 | + | 378 | WP_000854726.1 | TA system toxin CbtA family protein | Toxin |
| MJ253_RS22775 (4594255) | 4594255..4594542 | + | 288 | Protein_4474 | DUF5983 family protein | - |
| MJ253_RS22780 (4594635) | 4594635..4595863 | + | 1229 | WP_148116659.1 | IS3-like element ISEc27 family transposase | - |
| MJ253_RS22785 (4595873) | 4595873..4596079 | + | 207 | Protein_4476 | DUF5983 family protein | - |
| MJ253_RS22790 (4596091) | 4596091..4596288 | + | 198 | WP_000839269.1 | DUF957 domain-containing protein | - |
| MJ253_RS22795 (4596373) | 4596373..4597215 | + | 843 | WP_001548928.1 | DUF4942 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14164.10 Da Isoelectric Point: 7.8045
>T236296 WP_000854726.1 NZ_CP092493:4593881-4594258 [Citrobacter freundii]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
Download Length: 378 bp
>T236296 NZ_LR217818:c3395616-3395365 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA
Antitoxin
Download Length: 109 a.a. Molecular weight: 12301.97 Da Isoelectric Point: 7.0273
>AT236296 WP_001548930.1 NZ_CP092493:4593465-4593791 [Citrobacter freundii]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTFGSCGYVYLAVYPTPETKK
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTFGSCGYVYLAVYPTPETKK
Download Length: 327 bp
>AT236296 NZ_LR217818:c3395368-3395114 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|