Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1782853..1783355 Replicon chromosome
Accession NZ_CP092452
Organism Escherichia coli isolate TKEC21-59

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7I6H4L3
Locus tag MJJ11_RS08500 Protein ID WP_000767831.1
Coordinates 1783101..1783355 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag MJJ11_RS08495 Protein ID WP_001259255.1
Coordinates 1782853..1783104 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJJ11_RS08470 (1778030) 1778030..1779097 - 1068 WP_085448381.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
MJJ11_RS08475 (1779097) 1779097..1780167 - 1071 WP_085448380.1 histidinol-phosphate transaminase -
MJJ11_RS08480 (1780164) 1780164..1781468 - 1305 WP_085448379.1 histidinol dehydrogenase -
MJJ11_RS08485 (1781474) 1781474..1782373 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
MJJ11_RS08490 (1782519) 1782519..1782569 - 51 WP_001364200.1 his operon leader peptide -
MJJ11_RS08495 (1782853) 1782853..1783104 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
MJJ11_RS08500 (1783101) 1783101..1783355 + 255 WP_000767831.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
MJJ11_RS08505 (1783438) 1783438..1784262 + 825 WP_000754737.1 SDR family oxidoreductase -
MJJ11_RS08510 (1784308) 1784308..1785237 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
MJJ11_RS08515 (1785452) 1785452..1785514 + 63 WP_010723108.1 membrane protein YoeI -
MJJ11_RS08520 (1785504) 1785504..1786862 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
MJJ11_RS08525 (1787041) 1787041..1788099 + 1059 WP_000492321.1 thiosulfate utilization transporter TsuA/YeeE -
MJJ11_RS08530 (1788113) 1788113..1788340 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10231.67 Da        Isoelectric Point: 8.8202

>T236154 WP_000767831.1 NZ_CP092452:1783101-1783355 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTYDSLLIAAC
RYHY

Download         Length: 255 bp

>T236154 NZ_LR135415:45704-46054 [Enterococcus faecium]
ATGGTGAGAAAACCTAGACAAGGCGATATTCTATTATTGAATACAGCACCTCGATCTGGACACGAACAGACAGGTAAAAG
ACCTTATATTGTTTTAAGTCATGATATTATTGCGGATTATAGTAACGTTGTTACAGTTGCTCCAATTTCTAGTACAACTA
GAAACTATCCGCTATATGTAAATATAAACTCAGAATATGAAATGAAGACAACAGGAAAAGTATTATTAGATCAACTAACG
ACAATTGATTATGAAGCCAGAGAGTGTATTTTTTTGGAAAAAGCGCATGATAGTTTAGTTGAGGAGTTATTGATGAAAGT
TAGAACAGTTTTTCAAAAAGTAAGCAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT236154 WP_001259255.1 NZ_CP092452:1782853-1783104 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT236154 NZ_LR135415:45447-45710 [Enterococcus faecium]
ATGGAAATGTTACCTATAAAAAAATGGGGAAATAGTAATGGCCTTAGATTGCCAAAGTATATTATGGAATATCTTGGAAT
TCATACAGAAGACAAAGTGAAGATAATACAAGAAGAAGTAAACGGTCAGAAGCGGCTAATTATCGAAGCGGCTAATATAG
AAAATGAATTAACAATTGAACAGTTATTTGAAAATTACACTGATGAAAGAAATCATGTGACGATTCAAAATTTAGGTGAA
GCAGTAGGTAATGAAAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I6H4L3

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References