Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3401440..3402053 Replicon chromosome
Accession NZ_CP092430
Organism Mycolicibacter virginiensis strain DSM 100883

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MJO54_RS16505 Protein ID WP_046284282.1
Coordinates 3401652..3402053 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MJO54_RS16500 Protein ID WP_046284283.1
Coordinates 3401440..3401661 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJO54_RS16480 (MJO54_16445) 3396982..3398097 + 1116 WP_064888102.1 hypothetical protein -
MJO54_RS16485 (MJO54_16450) 3398100..3399098 - 999 WP_240175189.1 TIGR03617 family F420-dependent LLM class oxidoreductase -
MJO54_RS16490 (MJO54_16455) 3399114..3400100 - 987 WP_046284304.1 alpha/beta hydrolase -
MJO54_RS16495 (MJO54_16460) 3400199..3401173 + 975 WP_046284284.1 NADPH:quinone oxidoreductase family protein -
MJO54_RS16500 (MJO54_16465) 3401440..3401661 + 222 WP_046284283.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MJO54_RS16505 (MJO54_16470) 3401652..3402053 + 402 WP_046284282.1 type II toxin-antitoxin system VapC family toxin Toxin
MJO54_RS16510 (MJO54_16475) 3402107..3402928 + 822 WP_240175190.1 nuclear transport factor 2 family protein -
MJO54_RS16515 (MJO54_16480) 3402938..3403693 - 756 WP_046284280.1 DUF1295 domain-containing protein -
MJO54_RS16520 (MJO54_16485) 3403768..3404271 - 504 WP_064888107.1 STM3941 family protein -
MJO54_RS16525 (MJO54_16490) 3404342..3404719 - 378 WP_240175191.1 MerR family transcriptional regulator -
MJO54_RS16530 (MJO54_16495) 3404799..3405731 + 933 WP_240175192.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(8-133)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-45)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.77 Da        Isoelectric Point: 7.4030

>T236085 WP_046284282.1 NZ_CP092430:3401652-3402053 [Mycolicibacter virginiensis]
MAVTVTYLLDTHALLWALTAPSRLGRNAREVLTDRSVAIVVSSVSAWELSTKQRLGKLPQADAILGAYSRHLDRLGATRL
PITDEHALLAGRLDWDHRDPFDRMLAAQAIIQSMTLITGDAAFAGLAGVPMVW

Download         Length: 402 bp

>T236085 NZ_LR135294:41932-42117 [Enterococcus faecium]
ATGCCACTTACGGGAAAAGAAATGCTTAAGTTATTGAAAAAAAATGGCTGGGTTGAGCGAAGGCAAGAGGGATCTCATCA
TCATCTTTATAAGGATGGTGTTAGAATCACTGTTCCTGTTCATGCCAATCAAGATCTTGGCCGAGGACTTGAGCAAAAAA
TTTTAAAGGATGCGGGATTGAAATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8033.06 Da        Isoelectric Point: 4.1220

>AT236085 WP_046284283.1 NZ_CP092430:3401440-3401661 [Mycolicibacter virginiensis]
MKQVKVQYAKTHLSALIAAVEGGEEFVIARGDSPAARLVPLASQDDRELGFVAYAVPDEFFDPLPEEELTAWQ

Download         Length: 222 bp

>AT236085 NZ_LR135294:42151-42582 [Enterococcus faecium]
ATGTTAAGTGAGCCTTTAGCAAAAACCTATCCTGCTATTTTTAGCCCAGAAGAAGGTGGTGGGTACTTTATTGAATTTCC
TGATGTTCAAGGTGCTTACACAGGAATTAACGAAGACGATATATCTTATGGAATTGCTATGGCACAAGAGGTGTTAGGTA
TGGTTTTAGCAGATTATATTGAGCATGAAGATCTACTTCCAGAACCAACACCAATCAATAAGATTTCTGTTGAAGATGAT
TCTTTTACTACTTTAATTCGTGTAGATGTTGCCAAATATTTGAAAGACACAGAACTTGTCAAAAAAACCTTAACAATTCC
TCAATGGGCGGATAAGCTAGGCAAAAGGGCTGGCATAAATTTTTCAGTCCTTCTAACAGAATCAATTGCAGATAAAGCAG
ATAACATTCTTCGTTCTGGAAGAAATAATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References