Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1450485..1451155 Replicon chromosome
Accession NZ_CP092430
Organism Mycolicibacter virginiensis strain DSM 100883

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MJO54_RS07165 Protein ID WP_046285331.1
Coordinates 1450485..1450913 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MJO54_RS07170 Protein ID WP_046285332.1
Coordinates 1450919..1451155 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJO54_RS07140 (MJO54_07105) 1446229..1446957 + 729 WP_046286761.1 3'(2'),5'-bisphosphate nucleotidase CysQ -
MJO54_RS07145 (MJO54_07110) 1446983..1447459 + 477 WP_046286760.1 RrF2 family transcriptional regulator -
MJO54_RS07150 (MJO54_07115) 1447571..1447960 - 390 WP_046286759.1 VOC family protein -
MJO54_RS07155 (MJO54_07120) 1448019..1448909 + 891 WP_064889241.1 LLM class flavin-dependent oxidoreductase -
MJO54_RS07160 (MJO54_07125) 1449041..1450480 + 1440 WP_046285330.1 DUF4185 domain-containing protein -
MJO54_RS07165 (MJO54_07130) 1450485..1450913 - 429 WP_046285331.1 PIN domain-containing protein Toxin
MJO54_RS07170 (MJO54_07135) 1450919..1451155 - 237 WP_046285332.1 CopG family transcriptional regulator Antitoxin
MJO54_RS07175 (MJO54_07140) 1451249..1452166 - 918 WP_046285333.1 LLM class F420-dependent oxidoreductase -
MJO54_RS07180 (MJO54_07145) 1452229..1452924 - 696 WP_240175767.1 hypothetical protein -
MJO54_RS07185 (MJO54_07150) 1452924..1454318 - 1395 WP_052741259.1 hypothetical protein -
MJO54_RS07190 (MJO54_07155) 1454325..1454684 - 360 WP_046285334.1 type VII secretion target -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15784.87 Da        Isoelectric Point: 5.8798

>T236083 WP_046285331.1 NZ_CP092430:c1450913-1450485 [Mycolicibacter virginiensis]
MRSLLDVNVLLALLDRDHVDHERARTWLDTEIDHGWASCAITQNGFVRIISQPRYPNPVTPNYAIGMLAQATGTRYHQFW
TCAVSVLDADVVDPARVHSSKQVTDAYLLALAVANDGRFVTFDQSIALTTVPGAEDRHLTIL

Download         Length: 429 bp

>T236083 NZ_LR135293:194575-194841 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8712.77 Da        Isoelectric Point: 6.8806

>AT236083 WP_046285332.1 NZ_CP092430:c1451155-1450919 [Mycolicibacter virginiensis]
MRTTLSIDDDVLLAVKERAHRERRPVGEVLSELARQALTRHDNPTKGSESFHGFAPLPHRGTAVSNALIDRLRDEEGV

Download         Length: 237 bp

>AT236083 NZ_LR135293:194312-194575 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References