Detailed information of TA system TA236081

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PHD(antitoxin)
• Location: 730578..731248
• Replicon: chromosome
• Accession: NZ_CP092430
• Organism: Mycolicibacter virginiensis strain DSM 100883

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MJO54_RS03595
• Protein ID: WP_240175667.1
• Coordinates: 730578..730976 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MJO54_RS03600
• Protein ID: WP_220695604.1
• Coordinates: 730976..731248 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJO54_RS03575 (MJO54_03550)	726899..727516	+	618	WP_240175664.1	TetR/AcrR family transcriptional regulator	-
MJO54_RS03580 (MJO54_03555)	727554..729146	+	1593	WP_240175665.1	peptide chain release factor 3	-
MJO54_RS03585 (MJO54_03560)	729155..730033	-	879	WP_109413485.1	NYN domain-containing protein	-
MJO54_RS03590 (MJO54_03565)	730229..730537	-	309	WP_240175666.1	hypothetical protein	-
MJO54_RS03595 (MJO54_03570)	730578..730976	-	399	WP_240175667.1	type II toxin-antitoxin system VapC family toxin	Toxin
MJO54_RS03600 (MJO54_03575)	730976..731248	-	273	WP_220695604.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
MJO54_RS03605 (MJO54_03580)	731289..733028	-	1740	WP_240175668.1	exodeoxyribonuclease V subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-101)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-44)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14162.30 Da
• Isoelectric Point: 5.7185

>T236081 WP_240175667.1 NZ_CP092430:c730976-730578 [Mycolicibacter virginiensis]
VLYLDTSALVKLIRREPESDALVDWLAAQQPTPWVSSTLIEAELPRAIRRAEPSLLVDVPATLARVSRYEVNEVVRAAAA
ALPDPTLRSLDAIHLATSHAVFGARLTAFVAYDGRLLAAAEAIGLPTVSPGR

Nucleotide

• Length: 399 bp

>T236081 NZ_LR135287:513297-513638 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9890.21 Da
• Isoelectric Point: 6.2260

>AT236081 WP_220695604.1 NZ_CP092430:c731248-730976 [Mycolicibacter virginiensis]
MSEVPVRELNQNTAGVLARVKRGEHLEITERGTVVARLVPAQDSPLAEMIKAGQLHPATVSGPVPRPTGPVRTDHEAGDL
LREMRDDERY

Nucleotide

• Length: 273 bp

>AT236081 NZ_LR135287:513067-513297 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG