Detailed information of TA system TA236080

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-CcdA
• Location: 62775..63403
• Replicon: chromosome
• Accession: NZ_CP092430
• Organism: Mycolicibacter virginiensis strain DSM 100883

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MJO54_RS00305
• Protein ID: WP_259602755.1
• Coordinates: 62775..63188 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MJO54_RS00310
• Protein ID: WP_046284904.1
• Coordinates: 63185..63403 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJO54_RS00295 (MJO54_00295)	60598..62097	-	1500	WP_065153598.1	type VII secretion protein EccB	-
MJO54_RS00300 (MJO54_00300)	62242..62670	+	429	WP_233428794.1	DUF4226 domain-containing protein	-
MJO54_RS00305 (MJO54_00305)	62775..63188	-	414	WP_259602755.1	type II toxin-antitoxin system VapC family toxin	Toxin
MJO54_RS00310 (MJO54_00310)	63185..63403	-	219	WP_046284904.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
MJO54_RS00315 (MJO54_00315)	63985..64626	+	642	WP_065153596.1	hypothetical protein	-
MJO54_RS23565	64644..65603	-	960	WP_065153595.1	hypothetical protein	-
MJO54_RS00330 (MJO54_00330)	65600..66913	-	1314	WP_240176025.1	DUF5631 domain-containing protein	-
MJO54_RS00335 (MJO54_00335)	67334..67627	+	294	WP_065153593.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (13-133)

Antitoxin

• Post-segregation antitoxin CcdA (3-45)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 14732.96 Da
• Isoelectric Point: 7.3212

>T236080 WP_259602755.1 NZ_CP092430:c63188-62775 [Mycolicibacter virginiensis]
VKPLSGSPAEQVVVDASAMVDLLARTQDRFTSVRARLAGTVMHAPAHFDAEVLSALGRMQRAGVLTVAQVGAALDQLRRA
PVTRHELSPLLAGAWARREILRLTDALYVELSDTADLVLLTTDQRLARAWPAAEAIS

Nucleotide

• Length: 414 bp

>T236080 NZ_CP092430:c63188-62775 [Mycolicibacter virginiensis]
GTGAAACCGCTCTCCGGTTCGCCGGCAGAGCAGGTGGTCGTGGACGCCAGTGCCATGGTGGACCTACTTGCTCGCACCCA
GGATCGGTTCACATCGGTACGTGCGCGGCTGGCCGGCACAGTGATGCACGCGCCGGCGCACTTTGATGCCGAGGTGCTAT
CGGCGCTGGGGCGCATGCAACGCGCCGGCGTGCTGACCGTTGCTCAGGTCGGGGCGGCACTGGATCAGCTACGACGGGCA
CCGGTAACTCGGCACGAACTCTCCCCGTTGCTTGCTGGAGCGTGGGCGCGGCGCGAGATTCTGCGCCTCACCGACGCCCT
CTACGTGGAACTTTCGGACACGGCAGATCTGGTGCTGCTCACCACGGACCAGCGGCTGGCGCGTGCTTGGCCTGCGGCCG
AAGCCATCAGCTGA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 7712.46 Da
• Isoelectric Point: 4.0780

>AT236080 WP_046284904.1 NZ_CP092430:c63403-63185 [Mycolicibacter virginiensis]
MARLNVYVPDDLAERARARGLNISALTQAAISAELENSATDSWLDGLEAWSTSARHDDVLTALDAARDELGA

Nucleotide

• Length: 219 bp

>AT236080 NZ_CP092430:c63403-63185 [Mycolicibacter virginiensis]
ATGGCTCGGCTGAACGTGTATGTTCCCGACGATTTGGCGGAGCGAGCCAGGGCGCGGGGACTGAACATCTCGGCGCTGAC
TCAGGCCGCGATCAGCGCTGAGTTGGAGAATTCCGCGACCGACAGCTGGCTTGACGGGCTAGAGGCCTGGAGCACAAGCG
CTCGACACGATGACGTGCTGACTGCGCTCGACGCCGCCCGCGATGAGCTCGGAGCGTGA