Detailed information of TA system TA235981

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): bsrG-as-bsrH/-
• Location: 2232321..2232485
• Replicon: chromosome
• Accession: NZ_CP092369
• Organism: Bacillus subtilis strain ZW

Toxin (Protein)

• Gene name: bsrG
• Uniprot ID: L8EAY0
• Locus tag: MID01_RS11390
• Protein ID: WP_009967548.1
• Coordinates: 2232321..2232437 (+)
• Length: 39 a.a.

Antitoxin (RNA)

Gene name	as-bsrH
Locus tag	-
Coordinates	2232432..2232485 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MID01_RS11350 (2227458)	2227458..2227850	+	393	WP_019712881.1	hypothetical protein	-
MID01_RS11355 (2227871)	2227871..2228122	+	252	WP_019712880.1	phage holin	-
MID01_RS11360 (2228250)	2228250..2229386	+	1137	WP_019712879.1	tetratricopeptide repeat protein	-
MID01_RS11365 (2229376)	2229376..2229552	+	177	WP_019712878.1	hypothetical protein	-
MID01_RS11370 (2229595)	2229595..2230823	-	1229	Protein_2195	UV damage repair protein UvrX	-
MID01_RS11375 (2230816)	2230816..2231148	-	333	WP_109962767.1	YolD-like family protein	-
MID01_RS11380 (2231322)	2231322..2231657	+	336	WP_041054825.1	hypothetical protein	-
MID01_RS11385 (2231701)	2231701..2232060	-	360	WP_041338710.1	hypothetical protein	-
MID01_RS11390 (2232321)	2232321..2232437	+	117	WP_009967548.1	type I toxin-antitoxin system toxin BsrG	Toxin
- (2232432)	2232432..2232485	-	54	NuclAT_2	-	Antitoxin
- (2232432)	2232432..2232485	-	54	NuclAT_2	-	Antitoxin
- (2232432)	2232432..2232485	-	54	NuclAT_2	-	Antitoxin
- (2232432)	2232432..2232485	-	54	NuclAT_2	-	Antitoxin
MID01_RS11395 (2232529)	2232529..2232987	-	459	WP_109962768.1	YrhA family protein	-
MID01_RS11400 (2233000)	2233000..2234886	-	1887	WP_109962769.1	T7SS effector LXG polymorphic toxin	-
MID01_RS11405 (2235019)	2235019..2235552	-	534	WP_109962770.1	SMI1/KNR4 family protein	-
MID01_RS11410 (2235637)	2235637..2235887	-	251	Protein_2203	hypothetical protein	-
MID01_RS11415 (2236067)	2236067..2236951	+	885	WP_109962771.1	endonuclease YokF	-
MID01_RS11420 (2236994)	2236994..2237467	-	474	WP_109962772.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2116127..2265019	148892

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-38)

Sequences

Toxin

Protein

• Length: 39 a.a.
• Molecular weight: 4336.39 Da
• Isoelectric Point: 10.1022

>T235981 WP_009967548.1 NZ_CP092369:2232321-2232437 [Bacillus subtilis]
MTVYESLMIMINFGGLILNTVLLIFNIMMIVTSSQKKK

Nucleotide

• Length: 117 bp

>T235981 NZ_LR134527:c1617584-1616991 [Bartonella elizabethae]
GTGGAGACGTATAAGGGGAGTGGTGATCCTTATACTGATCCTAAAACTGGTGTGATGTATAACCGGTTTGAAATTCAGGA
TAAAACCGTACTGGAGCGTGTAGAATCCACTTTCGCTTATGTAAGGTCTTTTGAGCTTATGCGTGCTGCTAGGGGTGGTA
AGTTTGATCTCAATCATATGAAAGATATTCACAAGAAGCTATTTGGTGACGTCTATGAATGGGCGGGAGAGATCCGTTCA
ATAGATATTACCAAAGGTGGTTGTTTATTTGCTTATCATCATCAGATTGAAAGTTATACGCCGAAGATTACACAGCAGCT
TGCCAAAGAACAATATCTGCGTGGTCTTGATGCGGATGAATTCAGCCAGAGAGCTGGATATTACATGGGTGAAATAAATG
CGTTGCATCCCTTTCGAGAGGGAAATGGACGCACTCAGCGTGAATTTATTGGTCAACTTGCTCGTGAGGCTGGTTATCAT
ATCAACTGGAAGGGTATCACGCGACAAGAAATGATAGAGGCATCAATTGAGGCACTTTATGGTACTTCTGAATTACTGTC
TGAGCTTATTCGTAAGAACCTCAATCTCTTATAA

Antitoxin

Nucleotide

• Length: 54 bp

>AT235981 NZ_CP092369:c2232485-2232432 [Bacillus subtilis]
AAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAAACTCAAGGGAAGGTCTATTT

Structures

Toxin

• AlphaFold DB: A0A7Z7EVU9

Antitoxin