Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1703454..1704035 Replicon chromosome
Accession NZ_CP092360
Organism Wielerella bovis strain 07LB258

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag MIS31_RS08825 Protein ID WP_249446465.1
Coordinates 1703454..1703783 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag MIS31_RS08830 Protein ID WP_249446466.1
Coordinates 1703790..1704035 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIS31_RS08810 (MIS31_08810) 1698517..1699950 + 1434 WP_249446462.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
MIS31_RS08815 (MIS31_08815) 1700089..1701102 + 1014 WP_249446463.1 CAP domain-containing protein -
MIS31_RS08820 (MIS31_08820) 1701561..1703009 - 1449 WP_249446464.1 metalloprotease TldD -
MIS31_RS08825 (MIS31_08825) 1703454..1703783 - 330 WP_249446465.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MIS31_RS08830 (MIS31_08830) 1703790..1704035 - 246 WP_249446466.1 antitoxin Antitoxin
MIS31_RS08835 (MIS31_08835) 1704237..1704623 - 387 WP_249446467.1 helix-turn-helix transcriptional regulator -
MIS31_RS08840 (MIS31_08840) 1704746..1705300 + 555 WP_249446468.1 hypothetical protein -
MIS31_RS08845 (MIS31_08845) 1705373..1708039 - 2667 WP_249446469.1 aminopeptidase N -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-107)

Antitoxin

Antitoxin PemI-like

(4-81)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12142.03 Da        Isoelectric Point: 10.1784

>T235956 WP_249446465.1 NZ_CP092360:c1703783-1703454 [Wielerella bovis]
MERGDIFLVNLDPTTGHEQQGTRPVLIISPKAFNALTQVPIVLPITTKSQFARTQGFAVHLDERTKTQGIVRTDQSRALD
IQARNGRKLETLPIDLMNEVLAKMATFLS

Download         Length: 330 bp

>T235956 NZ_LR134515:c1581769-1581398 [Actinobacillus pleuropneumoniae]
ATGTATGAAATAGTCTTTTATCGAGATAAGCGGGGGAGAGAACCCGTAAAAGAATTTCTGTTAAGGCTACTAAAAGAACG
GCAGGAAGGCAGTCGAGAACGATTACACAAAATCAGCCATCATTTGAGTATTTTACATTTGCACGGTACTCGAGCCGGTG
AGAATTATATTAAGCATTTGGAAGATCGTATTTGGCAGTTACGTCCGGTGGGCGATTGCCTGTTATTTGCAAGTATTATT
CGGGGAAAATTTGTGTTGTTGCATTATTTTGCCAAACAGAATTATCGAATTCCGAAACGAGAAATAGAACGTGCAAAAGT
TCGGTTGGCGGATTTACAGGAGAGAATAAAAGATGAGCCCTATTGGTTCTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8921.22 Da        Isoelectric Point: 4.9189

>AT235956 WP_249446466.1 NZ_CP092360:c1704035-1703790 [Wielerella bovis]
MYTVSLRKVGGSTMLAIPPALLQSLDLGKQVHLHTENGRLIIEPARPQYTLAELLAQCDPNAPRDVESQTWLDAPAVGQE
W

Download         Length: 246 bp

>AT235956 NZ_LR134515:c1581417-1581124 [Actinobacillus pleuropneumoniae]
ATGAGCCCTATTGGTTCTAGTTGGACATCGTTTGAACAAGAAATTTTTGACGAGTCGGAAATAGCGGAAACTCAGTTTCG
CATACGACTTATTTTAGAAATCATTGAAACCCGTCAGCAGCTCGGTATTTCTCAACGAAAATTGGAGAAATTAAGCGGCG
TAAAACAATCTATGATTGCTCGGGTAGAAAAAGGCTCGGTTAATCCGTCGTTGGCGACGGTATTAAAGTTGCTTGTGCCG
TTGGGGAAAACTTTACAAATCGTACCGTTAGATAAAAACAAAACGGTACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References