Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Rv0299-vapB/-
Location 364781..365352 Replicon chromosome
Accession NC_012207
Organism Mycobacterium bovis BCG str. Tokyo 172

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag JTY_RS01585 Protein ID WP_003401560.1
Coordinates 364781..365083 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag JTY_RS01590 Protein ID WP_003401563.1
Coordinates 365131..365352 (+) Length 74 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTY_RS01565 360205..361008 - 804 WP_003401540.1 hypothetical protein -
JTY_RS01570 361018..362415 - 1398 WP_003401544.1 sulfatase -
JTY_RS01575 362594..364414 + 1821 WP_003401546.1 PE family protein -
JTY_RS01580 364557..364784 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
JTY_RS01585 364781..365083 + 303 WP_003401560.1 toxin-antitoxin system toxin Toxin
JTY_RS01590 365131..365352 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
JTY_RS01595 365349..365774 + 426 WP_003401566.1 PIN domain nuclease -
JTY_RS01600 365911..366543 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
JTY_RS01605 366540..367448 + 909 WP_003900117.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(9-37)


Sequences


Toxin        


Download         Length: 101 a.a.        Molecular weight: 10442.16 Da        Isoelectric Point: 4.9609

>T23589 WP_003401560.1 NC_012207:364781-365083 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Download         Length: 303 bp

>T23589 NC_012207:364781-365083 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT23589 WP_003401563.1 NC_012207:365131-365352 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT23589 NC_012207:365131-365352 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References