Detailed information of TA system TA235629

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 3566393..3566915
• Replicon: chromosome
• Accession: NZ_CP092065
• Organism: Edwardsiella ictaluri strain S15-163

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C5BBL4
• Locus tag: MAY82_RS17385
• Protein ID: WP_015871319.1
• Coordinates: 3566393..3566674 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C5BBL3
• Locus tag: MAY82_RS17390
• Protein ID: WP_015871318.1
• Coordinates: 3566664..3566915 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MAY82_RS17370 (MAY82_17270)	3561780..3562556	+	777	WP_015871322.1	hypothetical protein	-
MAY82_RS17375 (MAY82_17275)	3562549..3564210	+	1662	WP_050977403.1	terminase	-
MAY82_RS17380 (MAY82_17280)	3564207..3566321	+	2115	WP_015871320.1	hypothetical protein	-
MAY82_RS17385 (MAY82_17285)	3566393..3566674	-	282	WP_015871319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MAY82_RS17390 (MAY82_17290)	3566664..3566915	-	252	WP_015871318.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MAY82_RS17395 (MAY82_17295)	3567203..3568204	+	1002	WP_107775275.1	hypothetical protein	-
MAY82_RS17400 (MAY82_17300)	3568222..3569476	+	1255	Protein_3355	DUF4043 family protein	-
MAY82_RS17405 (MAY82_17305)	3569635..3570030	+	396	WP_015871315.1	hypothetical protein	-
MAY82_RS17410 (MAY82_17310)	3570072..3570515	+	444	WP_015871314.1	hypothetical protein	-
MAY82_RS17415 (MAY82_17315)	3570536..3571096	+	561	WP_226092333.1	hypothetical protein	-
MAY82_RS17420 (MAY82_17320)	3571096..3571758	+	663	WP_015871312.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3531121..3595196	64075

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10783.62 Da
• Isoelectric Point: 10.6993

>T235629 WP_015871319.1 NZ_CP092065:c3566674-3566393 [Edwardsiella ictaluri]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Nucleotide

• Length: 282 bp

>T235629 NZ_LR134312:2624576-2624719 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9155.24 Da
• Isoelectric Point: 3.7550

>AT235629 WP_015871318.1 NZ_CP092065:c3566915-3566664 [Edwardsiella ictaluri]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Nucleotide

• Length: 252 bp

>AT235629 NZ_LR134312:c2624913-2624651 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: C5BBL4

Antitoxin

• AlphaFold DB: C5BBL3