Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 3573536..3574058 Replicon chromosome
Accession NZ_CP092062
Organism Edwardsiella ictaluri strain S00-1912

Toxin (Protein)


Gene name relE Uniprot ID C5BBL4
Locus tag MAY76_RS17350 Protein ID WP_015871319.1
Coordinates 3573536..3573817 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C5BBL3
Locus tag MAY76_RS17355 Protein ID WP_015871318.1
Coordinates 3573807..3574058 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAY76_RS17330 (MAY76_17195) 3568924..3569142 + 219 WP_278068664.1 hypothetical protein -
MAY76_RS17335 (MAY76_17200) 3569277..3569699 + 423 WP_232347283.1 hypothetical protein -
MAY76_RS17340 (MAY76_17205) 3569692..3571353 + 1662 WP_050977403.1 terminase -
MAY76_RS17345 (MAY76_17210) 3571350..3573464 + 2115 WP_015871320.1 hypothetical protein -
MAY76_RS17350 (MAY76_17215) 3573536..3573817 - 282 WP_015871319.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MAY76_RS17355 (MAY76_17220) 3573807..3574058 - 252 WP_015871318.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MAY76_RS17360 (MAY76_17225) 3574346..3575347 + 1002 WP_107775275.1 hypothetical protein -
MAY76_RS17365 (MAY76_17230) 3575365..3576621 + 1257 WP_015871316.1 N4-gp56 family major capsid protein -
MAY76_RS17370 (MAY76_17235) 3576779..3577174 + 396 WP_015871315.1 hypothetical protein -
MAY76_RS17375 (MAY76_17240) 3577215..3577658 + 444 WP_015871314.1 hypothetical protein -
MAY76_RS17380 (MAY76_17245) 3577679..3578239 + 561 WP_226092333.1 hypothetical protein -
MAY76_RS17385 (MAY76_17250) 3578239..3578901 + 663 WP_015871312.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3538257..3598479 60222


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10783.62 Da        Isoelectric Point: 10.6993

>T235623 WP_015871319.1 NZ_CP092062:c3573817-3573536 [Edwardsiella ictaluri]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Download         Length: 282 bp

>T235623 NZ_LR134312:c2546134-2545982 [Enterococcus faecalis]
GTGGTGCGTATGAGCGTACTTCCAAAATTTACGGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCT
AGGTTTTGGTATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9155.24 Da        Isoelectric Point: 3.7550

>AT235623 WP_015871318.1 NZ_CP092062:c3574058-3573807 [Edwardsiella ictaluri]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Download         Length: 252 bp

>AT235623 NZ_LR134312:2546238-2546381 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAACA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C5BBL4

Antitoxin

Source ID Structure
AlphaFold DB C5BBL3

References