Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2262969..2263632 Replicon chromosome
Accession NZ_CP092062
Organism Edwardsiella ictaluri strain S00-1912

Toxin (Protein)


Gene name cptA Uniprot ID C5BAS3
Locus tag MAY76_RS10865 Protein ID WP_015872556.1
Coordinates 2263216..2263632 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID C5BAS4
Locus tag MAY76_RS10860 Protein ID WP_015872557.1
Coordinates 2262969..2263235 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAY76_RS10840 (MAY76_10760) 2258469..2259119 - 651 WP_035609190.1 hemolysin III family protein -
MAY76_RS10845 (MAY76_10765) 2259728..2260600 + 873 WP_015872560.1 nucleoside-specific channel-forming protein Tsx -
MAY76_RS10850 (MAY76_10770) 2260762..2261574 + 813 Protein_2078 shikimate 5-dehydrogenase -
MAY76_RS10855 (MAY76_10775) 2261626..2262621 - 996 WP_015872558.1 tRNA-modifying protein YgfZ -
MAY76_RS10860 (MAY76_10780) 2262969..2263235 + 267 WP_015872557.1 FAD assembly factor SdhE Antitoxin
MAY76_RS10865 (MAY76_10785) 2263216..2263632 + 417 WP_015872556.1 protein YgfX Toxin
MAY76_RS10870 (MAY76_10790) 2263657..2264169 - 513 WP_015872555.1 flavodoxin FldB -
MAY76_RS10875 (MAY76_10795) 2264327..2265226 + 900 WP_015872554.1 site-specific tyrosine recombinase XerD -
MAY76_RS10880 (MAY76_10800) 2265254..2265970 + 717 WP_015872553.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MAY76_RS10885 (MAY76_10805) 2265975..2267708 + 1734 WP_015872552.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16145.89 Da        Isoelectric Point: 11.3233

>T235621 WP_015872556.1 NZ_CP092062:2263216-2263632 [Edwardsiella ictaluri]
VALWRCNVHASWRTQVMFLLGHGALVLAILLAPWPENYSVFWLILLVAVIFECIRSQRLIARNSGELQRLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGTPCRRRLWLAADSMSREEWGQLRRALLDTGDDRV

Download         Length: 417 bp

>T235621 NZ_LR134312:c2476598-2476470 [Enterococcus faecalis]
ATGCACTTTAACGAAAGGAGCATTTTTTTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGC
ACTACTGATTTTCGGTATCCTTGAAGCAACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10364.92 Da        Isoelectric Point: 5.6951

>AT235621 WP_015872557.1 NZ_CP092062:2262969-2263235 [Edwardsiella ictaluri]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLSCDDPELFKWLMNQGKPDDTDLARMITLIQTRN
KERGPLAL

Download         Length: 267 bp

>AT235621 NZ_LR134312:2476346-2476525 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C5BAS3

Antitoxin

Source ID Structure
AlphaFold DB C5BAS4

References