Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4263025..4263806 Replicon chromosome
Accession NZ_CP091999
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N16-1393

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag MA802_RS20660 Protein ID WP_000625911.1
Coordinates 4263025..4263516 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag MA802_RS20665 Protein ID WP_001271379.1
Coordinates 4263513..4263806 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA802_RS20635 (4258161) 4258161..4260599 - 2439 WP_023224120.1 F4 (K88) fimbrial usher FaeD -
MA802_RS20640 (4260609) 4260609..4261148 - 540 WP_000721295.1 type 1 fimbrial protein -
MA802_RS20645 (4261183) 4261183..4261473 - 291 WP_000773469.1 PapB/FocB family fimbrial expression transcriptional regulator -
MA802_RS20650 (4262060) 4262060..4262287 + 228 WP_001112992.1 hypothetical protein -
MA802_RS20655 (4262562) 4262562..4262810 - 249 Protein_4038 IS481 family transposase -
MA802_RS20660 (4263025) 4263025..4263516 - 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
MA802_RS20665 (4263513) 4263513..4263806 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
MA802_RS20670 (4264124) 4264124..4264345 + 222 WP_052939504.1 hypothetical protein -
MA802_RS20675 (4264611) 4264611..4265486 + 876 WP_023205266.1 AraC family transcriptional regulator -
MA802_RS20680 (4265483) 4265483..4265770 + 288 WP_072103482.1 transcriptional regulator RtsB -
MA802_RS20685 (4265763) 4265763..4265945 - 183 WP_072106065.1 ATP-binding cassette domain-containing protein -
MA802_RS20690 (4265965) 4265965..4266064 + 100 Protein_4045 hypothetical protein -
MA802_RS20695 (4266112) 4266112..4266306 + 195 WP_223163373.1 hypothetical protein -
MA802_RS20700 (4266601) 4266601..4267506 - 906 WP_001268192.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4250902..4265945 15043


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T235422 WP_000625911.1 NZ_CP091999:c4263516-4263025 [Salmonella enterica subsp. enterica serovar Kentucky]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T235422 NZ_LR134263:879399-879752 [Staphylococcus delphini]
ATGAAGCGCGGAGACGTCTATTTAGCAGATTTATCACCAGTACAGGGCTCTGAACAGGGGGGAGTAAGGCCCGTGGTCAT
TATCCAAAATGACACTGGTAATAAGTATAGTCCCACTGTGATTGTAGCCGCAATTACTGGTCGGATTAATAAGGCAAAGA
TACCAACGCATGTCGAAATCGAAAAAAATAAATATAAGCTCGATAAAGATTCTGTTATTTTACTAGAACAAATTCGAACA
GTCGATAAGAAACGATTAAAAGAAAAGTTAACGTTTTTGTCTGAGAAGAAGATGAAAGAAGTTAATAATGCGATTGGTAT
TAGTTTAGGACTGCACATGAATCATCATAAATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT235422 WP_001271379.1 NZ_CP091999:c4263806-4263513 [Salmonella enterica subsp. enterica serovar Kentucky]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT235422 NZ_LR134263:879228-879398 [Staphylococcus delphini]
ATGTCAGCATTCAATCAAACAAGATTTAAAAATTTAGAACAGTCGTTAAAAGAAGGTTATGTACAGATGGCAGATTTAAA
TCTCTCCCTAGCCACTGAGGCGTATCCAGTTGAATGTGAAGCTTGCGATTGTAATGAATCACACTTGACAACTGATTATA
AGGAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References