Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3388839..3389459 Replicon chromosome
Accession NZ_CP091999
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N16-1393

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MA802_RS16560 Protein ID WP_001280991.1
Coordinates 3389241..3389459 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag MA802_RS16555 Protein ID WP_000344807.1
Coordinates 3388839..3389213 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA802_RS16545 (3383978) 3383978..3385171 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MA802_RS16550 (3385194) 3385194..3388343 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
MA802_RS16555 (3388839) 3388839..3389213 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
MA802_RS16560 (3389241) 3389241..3389459 + 219 WP_001280991.1 HHA domain-containing protein Toxin
MA802_RS16565 (3389638) 3389638..3390189 + 552 WP_001278793.1 maltose O-acetyltransferase -
MA802_RS16570 (3390307) 3390307..3390777 + 471 WP_000136183.1 YlaC family protein -
MA802_RS16575 (3390833) 3390833..3390973 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
MA802_RS16580 (3390979) 3390979..3391239 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
MA802_RS16585 (3391464) 3391464..3393014 + 1551 WP_000213145.1 EAL domain-containing protein -
MA802_RS16595 (3393245) 3393245..3393634 + 390 WP_023224410.1 MGMT family protein -
MA802_RS16600 (3393667) 3393667..3394236 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T235417 WP_001280991.1 NZ_CP091999:3389241-3389459 [Salmonella enterica subsp. enterica serovar Kentucky]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T235417 NZ_LR134248:c3561460-3561062 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT235417 WP_000344807.1 NZ_CP091999:3388839-3389213 [Salmonella enterica subsp. enterica serovar Kentucky]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT235417 NZ_LR134248:c3561756-3561463 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References