Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 108255..108894 Replicon chromosome
Accession NZ_CP091985
Organism Burkholderia vietnamiensis strain FDAARGOS_721

Toxin (Protein)


Gene name vapC Uniprot ID A0A132DRA7
Locus tag FOC29_RS16455 Protein ID WP_011883463.1
Coordinates 108255..108674 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A132DHM6
Locus tag FOC29_RS16460 Protein ID WP_011883461.1
Coordinates 108661..108894 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC29_RS16430 (FOC29_16420) 103678..104034 - 357 WP_011883473.1 BON domain-containing protein -
FOC29_RS16435 (FOC29_16425) 104503..105936 + 1434 WP_011883471.1 TAXI family TRAP transporter solute-binding subunit -
FOC29_RS16440 (FOC29_16430) 106031..106669 + 639 WP_046426269.1 2-hydroxychromene-2-carboxylate isomerase -
FOC29_RS16445 (FOC29_16435) 106739..107683 + 945 WP_059454482.1 LysR family transcriptional regulator -
FOC29_RS16450 (FOC29_16440) 107724..108125 - 402 WP_014722533.1 polyketide cyclase -
FOC29_RS16455 (FOC29_16445) 108255..108674 - 420 WP_011883463.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC29_RS16460 (FOC29_16450) 108661..108894 - 234 WP_011883461.1 DNA-binding protein Antitoxin
FOC29_RS16465 (FOC29_16455) 109221..109874 - 654 WP_045578499.1 xanthine dehydrogenase accessory protein XdhC -
FOC29_RS16470 (FOC29_16460) 109962..112325 - 2364 WP_060042889.1 xanthine dehydrogenase molybdopterin binding subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15649.85 Da        Isoelectric Point: 6.0999

>T235343 WP_011883463.1 NZ_CP091985:c108674-108255 [Burkholderia vietnamiensis]
MFLVDTNVISEVRKRERADKGVMAFFRKAAQDDADLYLSVVTVGELRRGVEIIRHRGDKSQATRLENWLDGVLREFASNI
LAVDEEIGQLWGRLRVPHPEHSLDKLIAATALIHDLIVVTRNVDDFAGTGARVLNPFES

Download         Length: 420 bp

>T235343 NZ_LR134239:c3514856-3514440 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTTGA
ATTTATATTATGAATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8379.44 Da        Isoelectric Point: 5.0644

>AT235343 WP_011883461.1 NZ_CP091985:c108894-108661 [Burkholderia vietnamiensis]
MATLLVRNVDEELVQSLRERAAANGRSAEAEHREILAKALRAPQRKTFAQVLMSIPNVGTDADFARVDDGEAANVFG

Download         Length: 234 bp

>AT235343 NZ_LR134239:c3515152-3514859 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A132DRA7

Antitoxin

Source ID Structure
AlphaFold DB A0A132DHM6

References