Detailed information of TA system TA023518

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 1256788..1257485
• Replicon: chromosome
• Accession: NC_011979
• Organism: Geobacter daltonii FRC-32

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: B9M396
• Locus tag: GEOB_RS05705
• Protein ID: WP_012646235.1
• Coordinates: 1257066..1257485 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B9M395
• Locus tag: GEOB_RS05700
• Protein ID: WP_012646234.1
• Coordinates: 1256788..1257069 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GEOB_RS05680	1252279..1253019	+	741	WP_012646230.1	right-handed parallel beta-helix repeat-containing protein	-
GEOB_RS05685	1253306..1254473	+	1168	Protein_1128	Fic family protein	-
GEOB_RS05690	1254573..1255892	-	1320	WP_012646232.1	diaminopimelate decarboxylase	-
GEOB_RS05695	1256176..1256694	+	519	WP_041267364.1	tRNA (N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase TrmO	-
GEOB_RS05700	1256788..1257069	+	282	WP_012646234.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GEOB_RS05705	1257066..1257485	+	420	WP_012646235.1	type II toxin-antitoxin system VapC family toxin	Toxin
GEOB_RS05710	1257531..1257809	+	279	WP_012646236.1	hypothetical protein	-
GEOB_RS19225	1257837..1258439	+	603	WP_012646237.1	sel1 repeat family protein	-
GEOB_RS19230	1258561..1260243	-	1683	WP_195892561.1	hypothetical protein	-
GEOB_RS05725	1260601..1262340	-	1740	WP_012646239.1	DNA polymerase/3'-5' exonuclease PolX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (13-63)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15392.78 Da
• Isoelectric Point: 4.4605

>T23518 WP_012646235.1 NC_011979:1257066-1257485 [Geobacter daltonii FRC-32]
VKYLLDTCLISELVKKEPNPAVVNWLDEQEEQSLFLSVLNLGELQKGISKLPDGSKKDELQAWVALDLVERFTGRILDID
LETALCWGELQGMAEQKGEKLPVMDSLIAATATAHGLVVVTRNVKDMERCGGRVCNPWG

Nucleotide

• Length: 420 bp

>T23518 NC_011979:1257066-1257485 [Geobacter daltonii FRC-32]
GTGAAATACCTGCTTGATACTTGTCTGATTTCCGAGCTGGTGAAAAAAGAGCCGAACCCTGCAGTGGTCAATTGGTTGGA
CGAGCAGGAAGAGCAATCCCTTTTTCTCAGTGTTCTGAATTTGGGAGAGTTGCAGAAAGGGATCAGCAAACTCCCCGATG
GCTCCAAAAAAGATGAGCTTCAGGCCTGGGTCGCCCTTGACCTGGTGGAAAGGTTCACCGGACGCATCCTGGACATTGAT
CTGGAAACCGCTCTCTGCTGGGGGGAACTCCAGGGAATGGCGGAGCAGAAGGGAGAGAAGTTACCGGTAATGGATTCTCT
CATTGCCGCCACCGCTACGGCCCATGGCTTGGTTGTGGTTACCCGCAATGTGAAGGATATGGAGCGATGTGGCGGAAGGG
TTTGCAATCCGTGGGGGTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10730.29 Da
• Isoelectric Point: 10.3374

>AT23518 WP_012646234.1 NC_011979:1256788-1257069 [Geobacter daltonii FRC-32]
MKSKKTDRLPHDREWQLQEAKNRLSQVIKLAQHDGPQTITLRGKPSAVVVSFDEYRKLTVPRTGLAKFFKESPLRDVELD
LSRSADISREVEL

Nucleotide

• Length: 282 bp

>AT23518 NC_011979:1256788-1257069 [Geobacter daltonii FRC-32]
ATGAAATCTAAAAAAACGGATCGCTTGCCCCATGACCGTGAATGGCAGCTTCAGGAAGCCAAGAACCGCTTGAGCCAGGT
AATTAAACTGGCTCAGCATGATGGTCCGCAGACGATTACCCTACGCGGCAAACCTTCTGCTGTCGTCGTATCGTTTGATG
AGTATCGCAAGCTGACCGTGCCGCGTACCGGCCTGGCCAAGTTTTTCAAGGAATCTCCCCTGCGTGATGTGGAGCTCGAT
CTCAGCCGCAGTGCCGATATATCCCGCGAGGTGGAGCTGTGA

Structures

Toxin

• AlphaFold DB: B9M396

Antitoxin

• AlphaFold DB: B9M395