Detailed information of TA system TA234914

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1636375..1636954
• Replicon: chromosome
• Accession: NZ_CP091875
• Organism: Staphylococcus aureus strain MN8

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: MAK07_RS07790
• Protein ID: WP_001025401.1
• Coordinates: 1636709..1636954 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1636375..1636740 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MAK07_RS07750 (1633117)	1633117..1633673	-	557	Protein_1526	DUF2815 family protein	-
MAK07_RS07755 (1633699)	1633699..1634865	-	1167	WP_000762529.1	DUF2800 domain-containing protein	-
MAK07_RS07760 (1634862)	1634862..1635224	-	363	WP_000985972.1	hypothetical protein	-
MAK07_RS07765 (1635239)	1635239..1635562	-	324	WP_000174999.1	hypothetical protein	-
MAK07_RS07770 (1635641)	1635641..1635802	-	162	WP_001285948.1	DUF1270 domain-containing protein	-
MAK07_RS07775 (1635815)	1635815..1636078	-	264	WP_001124194.1	helix-turn-helix domain-containing protein	-
MAK07_RS07780 (1636105)	1636105..1636320	-	216	WP_001097552.1	hypothetical protein	-
MAK07_RS07785 (1636375)	1636375..1636740	+	366	WP_001128433.1	hypothetical protein	Antitoxin
MAK07_RS07790 (1636709)	1636709..1636954	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
MAK07_RS07795 (1637021)	1637021..1637401	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
MAK07_RS07800 (1637388)	1637388..1637585	-	198	WP_001148860.1	hypothetical protein	-
MAK07_RS07805 (1637655)	1637655..1637867	+	213	WP_000362644.1	hypothetical protein	-
MAK07_RS07810 (1637908)	1637908..1638057	-	150	WP_000771849.1	hypothetical protein	-
MAK07_RS07815 (1638072)	1638072..1638515	-	444	WP_000435362.1	hypothetical protein	-
MAK07_RS07820 (1638533)	1638533..1638757	-	225	WP_000333485.1	DUF739 family protein	-
MAK07_RS07825 (1638919)	1638919..1639299	+	381	WP_001089477.1	helix-turn-helix domain-containing protein	-
MAK07_RS07830 (1639321)	1639321..1639779	+	459	WP_000521395.1	hypothetical protein	-
MAK07_RS07835 (1639797)	1639797..1640231	+	435	WP_000755719.1	hypothetical protein	-
MAK07_RS07840 (1640260)	1640260..1640655	+	396	WP_000449656.1	hypothetical protein	-
MAK07_RS07845 (1640854)	1640854..1641204	-	351	WP_223200492.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	ebp / gnd	1582334..1668100	85766

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T234914 WP_001025401.1 NZ_CP091875:c1636954-1636709 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T234914 NZ_LR134139:c1886174-1886022 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Nucleotide

• Length: 366 bp

>AT234914 NZ_CP091875:1636375-1636740 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin