Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 213409..214204 Replicon chromosome
Accession NZ_CP091836
Organism Escherichia coli strain SWYHX138.33gt

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag L7H17_RS01030 Protein ID WP_000854914.1
Coordinates 213830..214204 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7UP42
Locus tag L7H17_RS01025 Protein ID WP_001280955.1
Coordinates 213409..213783 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L7H17_RS00995 (209197) 209197..210903 + 1707 Protein_196 AIDA repeat-containing protein -
L7H17_RS01000 (210898) 210898..210982 - 85 Protein_197 hypothetical protein -
L7H17_RS01005 (211076) 211076..211894 + 819 WP_001234682.1 DUF932 domain-containing protein -
L7H17_RS01010 (211985) 211985..212470 + 486 WP_000214398.1 antirestriction protein -
L7H17_RS01015 (212486) 212486..212962 + 477 WP_001186738.1 RadC family protein -
L7H17_RS01020 (213025) 213025..213246 + 222 WP_001220314.1 DUF987 domain-containing protein -
L7H17_RS01025 (213409) 213409..213783 + 375 WP_001280955.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
L7H17_RS01030 (213830) 213830..214204 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
L7H17_RS01035 (214201) 214201..214691 + 491 Protein_204 DUF5983 family protein -
L7H17_RS01040 (214703) 214703..214900 + 198 WP_000839282.1 DUF957 domain-containing protein -
L7H17_RS01045 (214985) 214985..215827 + 843 WP_001280481.1 DUF4942 domain-containing protein -
L7H17_RS01055 (216298) 216298..217236 + 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
L7H17_RS01060 (217291) 217291..218028 + 738 WP_000283667.1 zinc-binding phosphatase -
L7H17_RS01065 (218052) 218052..218606 + 555 WP_001001921.1 molecular chaperone YcdY -
L7H17_RS01070 (218708) 218708..219199 + 492 WP_001300785.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - f17d-A / f17d-D / f17d-C / f17d-G / csgG / csgF / csgE / csgD / csgB / csgA / csgC 155761..224765 69004


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T234833 WP_000854914.1 NZ_CP091836:213830-214204 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T234833 NZ_LR134091:c2436583-2436476 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13767.59 Da        Isoelectric Point: 6.6248

>AT234833 WP_001280955.1 NZ_CP091836:213409-213783 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT234833 NZ_LR134091:2436399-2436459 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9P0D0

References