Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2887742..2888354 Replicon chromosome
Accession NZ_CP091703
Organism Escherichia coli strain KOr021

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag L6L60_RS13750 Protein ID WP_000833473.1
Coordinates 2888169..2888354 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IWR9
Locus tag L6L60_RS13745 Protein ID WP_000499744.1
Coordinates 2887742..2888152 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L60_RS13730 (2883254) 2883254..2884069 - 816 WP_000891823.1 AraC family transcriptional regulator -
L6L60_RS13735 (2884295) 2884295..2885695 + 1401 WP_000204811.1 MFS transporter -
L6L60_RS13740 (2885706) 2885706..2887670 + 1965 WP_001551835.1 glycoside hydrolase family 127 protein -
L6L60_RS13745 (2887742) 2887742..2888152 - 411 WP_000499744.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L6L60_RS13750 (2888169) 2888169..2888354 - 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
L6L60_RS13755 (2888623) 2888623..2890161 - 1539 WP_001551836.1 aldehyde dehydrogenase AldB -
L6L60_RS13760 (2890362) 2890362..2891513 - 1152 WP_000741501.1 L-threonine dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T234608 WP_000833473.1 NZ_CP091703:c2888354-2888169 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

>T234608 NZ_LR130564:4280895-4281047 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15241.15 Da        Isoelectric Point: 4.5486

>AT234608 WP_000499744.1 NZ_CP091703:c2888152-2887742 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp

>AT234608 NZ_LR130564:c4280846-4280789 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB L4IWR9

References