Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1284907..1285702 Replicon chromosome
Accession NZ_CP091703
Organism Escherichia coli strain KOr021

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag L6L60_RS06190 Protein ID WP_000854914.1
Coordinates 1284907..1285281 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7UP42
Locus tag L6L60_RS06195 Protein ID WP_001280955.1
Coordinates 1285328..1285702 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L60_RS06160 (1281585) 1281585..1282289 + 705 WP_001241678.1 leucyl/phenylalanyl-tRNA--protein transferase -
L6L60_RS06165 (1282574) 1282574..1282792 + 219 WP_001040187.1 translation initiation factor IF-1 -
L6L60_RS06175 (1283283) 1283283..1284125 - 843 WP_001280481.1 DUF4942 domain-containing protein -
L6L60_RS06180 (1284210) 1284210..1284407 - 198 WP_000839282.1 DUF957 domain-containing protein -
L6L60_RS06185 (1284419) 1284419..1284910 - 492 WP_000976857.1 DUF5983 family protein -
L6L60_RS06190 (1284907) 1284907..1285281 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
L6L60_RS06195 (1285328) 1285328..1285702 - 375 WP_001280955.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
L6L60_RS06200 (1285865) 1285865..1286086 - 222 WP_001220314.1 DUF987 domain-containing protein -
L6L60_RS06205 (1286149) 1286149..1286625 - 477 WP_001186726.1 RadC family protein -
L6L60_RS06210 (1286641) 1286641..1287126 - 486 WP_000214307.1 antirestriction protein -
L6L60_RS06215 (1287218) 1287218..1288039 - 822 WP_001761104.1 DUF932 domain-containing protein -
L6L60_RS06220 (1288140) 1288140..1288348 - 209 Protein_1226 DUF905 family protein -
L6L60_RS06225 (1288449) 1288449..1288904 - 456 WP_000581506.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T234601 WP_000854914.1 NZ_CP091703:c1285281-1284907 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T234601 NZ_LR130564:2569839-2570117 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCATCGACTTGCTGTGATTGATGCGGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13767.59 Da        Isoelectric Point: 6.6248

>AT234601 WP_001280955.1 NZ_CP091703:c1285702-1285328 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT234601 NZ_LR130564:2570117-2570401 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAACGCCTGGAGTCTGGCAGAGGCTGAA
AAAACGGTGGATGTGTCGCGATTACGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9P0D0

References