Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 746569..747207 Replicon chromosome
Accession NZ_CP091703
Organism Escherichia coli strain KOr021

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9DHD1
Locus tag L6L60_RS03600 Protein ID WP_000813795.1
Coordinates 747031..747207 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L6L60_RS03595 Protein ID WP_076797675.1
Coordinates 746569..746985 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L60_RS03575 (741721) 741721..742662 - 942 WP_001251315.1 ABC transporter permease -
L6L60_RS03580 (742663) 742663..743676 - 1014 WP_001551095.1 ABC transporter ATP-binding protein -
L6L60_RS03585 (743694) 743694..744839 - 1146 WP_001551094.1 ABC transporter substrate-binding protein -
L6L60_RS03590 (745084) 745084..746490 - 1407 WP_001551093.1 PLP-dependent aminotransferase family protein -
L6L60_RS03595 (746569) 746569..746985 - 417 WP_076797675.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
L6L60_RS03600 (747031) 747031..747207 - 177 WP_000813795.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
L6L60_RS03605 (747429) 747429..747659 + 231 WP_023910283.1 YncJ family protein -
L6L60_RS03610 (747751) 747751..749712 - 1962 WP_001551090.1 23S rRNA 5-hydroxycytidine C2501 synthase -
L6L60_RS03615 (749785) 749785..750321 - 537 WP_001551089.1 DNA-binding transcriptional regulator SutR -
L6L60_RS03620 (750413) 750413..751585 + 1173 WP_001551088.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6747.80 Da        Isoelectric Point: 11.5666

>T234599 WP_000813795.1 NZ_CP091703:c747207-747031 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T234599 NZ_LR130564:2164998-2165101 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15220.55 Da        Isoelectric Point: 4.7386

>AT234599 WP_076797675.1 NZ_CP091703:c746985-746569 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPSNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT234599 NZ_LR130564:c2165139-2164868 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DHD1

Antitoxin

Source ID Structure

References