Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4342773..4343466 Replicon chromosome
Accession NZ_CP091691
Organism Escherichia coli strain KMi006

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag L6L65_RS21075 Protein ID WP_000415584.1
Coordinates 4342773..4343069 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag L6L65_RS21080 Protein ID WP_000650107.1
Coordinates 4343071..4343466 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L65_RS21040 (4337861) 4337861..4338175 - 315 WP_000958598.1 putative quinol monooxygenase -
L6L65_RS21045 (4338206) 4338206..4338787 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
L6L65_RS21050 (4339106) 4339106..4339438 + 333 WP_000917685.1 DUF2645 family protein -
L6L65_RS21055 (4339484) 4339484..4340833 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
L6L65_RS21060 (4340830) 4340830..4341489 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
L6L65_RS21065 (4341641) 4341641..4342033 + 393 WP_096930283.1 OB fold stress tolerance protein YgiW -
L6L65_RS21070 (4342086) 4342086..4342568 + 483 WP_000183505.1 GyrI-like domain-containing protein -
L6L65_RS21075 (4342773) 4342773..4343069 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
L6L65_RS21080 (4343071) 4343071..4343466 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
L6L65_RS21085 (4343599) 4343599..4345206 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
L6L65_RS21090 (4345344) 4345344..4347602 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T234541 WP_000415584.1 NZ_CP091691:4342773-4343069 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T234541 NZ_LR130555:2890133-2890240 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT234541 WP_000650107.1 NZ_CP091691:4343071-4343466 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT234541 NZ_LR130555:c2890080-2890019 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References