Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 419465..420144 Replicon chromosome
Accession NZ_CP091677
Organism Escherichia coli strain KFu022

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag L6L66_RS02025 Protein ID WP_136127287.1
Coordinates 419803..420144 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A8T5Z7I0
Locus tag L6L66_RS02020 Protein ID WP_032238500.1
Coordinates 419465..419782 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L66_RS01980 (414763) 414763..416538 + 1776 WP_032170439.1 ATP-binding protein -
L6L66_RS01985 (416758) 416758..417111 + 354 WP_032170438.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
L6L66_RS01990 (417159) 417159..417557 + 399 WP_172698543.1 ArsC/Spx/MgsR family protein -
L6L66_RS01995 (417588) 417588..417863 - 276 WP_172698544.1 ArsA-related P-loop ATPase -
L6L66_RS02000 (417881) 417881..417973 + 93 Protein_384 hypothetical protein -
L6L66_RS02005 (418065) 418065..418676 + 612 Protein_385 DUF932 domain-containing protein -
L6L66_RS02010 (418734) 418734..419216 + 483 WP_032238502.1 DNA repair protein RadC -
L6L66_RS02015 (419225) 419225..419398 + 174 WP_072003671.1 DUF987 family protein -
L6L66_RS02020 (419465) 419465..419782 + 318 WP_032238500.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
L6L66_RS02025 (419803) 419803..420144 + 342 WP_136127287.1 TA system toxin CbtA family protein Toxin
L6L66_RS02030 (420280) 420280..420924 - 645 WP_050488383.1 hypothetical protein -
L6L66_RS02035 (421477) 421477..421662 - 186 WP_000066585.1 hypothetical protein -
L6L66_RS02040 (421761) 421761..421904 - 144 Protein_392 HNH endonuclease -
L6L66_RS02045 (422041) 422041..422691 + 651 WP_001037977.1 HNH endonuclease -
L6L66_RS02050 (422699) 422699..423679 - 981 WP_032238610.1 sialate O-acetylesterase -
L6L66_RS02055 (423744) 423744..424850 - 1107 WP_172698545.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fimB / fimE / fimD / fimF / fimG / fimH 405758..440571 34813


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12908.03 Da        Isoelectric Point: 8.0292

>T234458 WP_136127287.1 NZ_CP091677:419803-420144 [Escherichia coli]
MKTLPAKISWAVKPCLSPVAVWQMLLTRLLEQHYGLTLDDTAFSDETVIKEHIDAGITLADAVNFLVDKYELVRIDRRGF
SWQEQSPYLRAVDILRARRAIGLLRRSINDAVL

Download         Length: 342 bp

>T234458 NZ_LR130544:c1839679-1839326 [Klebsiella variicola]
GTGTGGACGATTAAAACAACGGATATGTTTGATCGCTGGTTTACCTCGCTCAATGATATCGATCGGGCCAGCGTGCTGGC
AGCGCTGTTGGTCTTGCGGGAAAAGGGGCCGGGTTTGTCCAGACCTTATGCCGATACGATCAGAGGTTCCCGCTACAGCA
ACATGAAAGAGTTGCGTGTTCAGAGCCGGGGCGACCCAATACGGGCGTTTTTTGCTTTTGACCCGGCCCGTACCGGCATT
GTGCTTTGCGCCGGAAATAAGGTCGGCAATGAAAAACGGTTTTACCATGAGATGCTCGCGGTCGCAGATCGGGAATTCAC
AAACTGGCTTAACAGATTGAAAGAGAAGGAGTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11903.38 Da        Isoelectric Point: 6.6246

>AT234458 WP_032238500.1 NZ_CP091677:419465-419782 [Escherichia coli]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASITGKFSDAECRKLDETFPHFISQMESMLTTGELNPRHAHCVTLYH
NGFTCEADTFGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT234458 NZ_LR130544:c1839321-1839019 [Klebsiella variicola]
ATGGGCAGAACGCTGGAACAGCTTCTTATAGATGAAAAACCGGATGTCGTTGCCGAAGCTCAGGCTATTGCTAAGGATAT
CCTGCTTAATATTCATCTTGCCGAATTACGTGAGAAGGTGCAGAAGACCCAGGTAGAAATGGCGCAGAATTTAGGCATAA
AACAGCCTACCGTTGCAGGAATGGAAAAACCGGGCCGCGACCTGAAGCTCTCTACCCTTAAGCGTTATGTTGAAGCGGCG
GGTGGTAAGCTGCGGCTTGATGTTGAGCTCCCGGACGGGTCGCACTATGAGTTTGTTTTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References