Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4552017..4552539 Replicon chromosome
Accession NZ_CP091651
Organism Escherichia coli strain KTa008

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag L6L70_RS22010 Protein ID WP_001105433.1
Coordinates 4552017..4552307 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag L6L70_RS22015 Protein ID WP_000212715.1
Coordinates 4552297..4552539 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L70_RS21995 (4547185) 4547185..4548840 + 1656 WP_001550509.1 alpha,alpha-phosphotrehalase -
L6L70_RS22000 (4549234) 4549234..4551372 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
L6L70_RS22005 (4551552) 4551552..4552016 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L6L70_RS22010 (4552017) 4552017..4552307 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L6L70_RS22015 (4552297) 4552297..4552539 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L6L70_RS22020 (4552731) 4552731..4553117 - 387 WP_001232246.1 cytochrome b562 -
L6L70_RS22025 (4553300) 4553300..4554652 - 1353 WP_001162173.1 metalloprotease PmbA -
L6L70_RS22030 (4554746) 4554746..4555297 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
L6L70_RS22035 (4555447) 4555447..4556820 - 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T234248 WP_001105433.1 NZ_CP091651:c4552307-4552017 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T234248 NZ_LR027878:c2120241-2120065 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTCATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT234248 WP_000212715.1 NZ_CP091651:c4552539-4552297 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT234248 NZ_LR027878:2119942-2119997 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References