Detailed information of TA system TA234244

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 3374162..3374867
• Replicon: chromosome
• Accession: NZ_CP091651
• Organism: Escherichia coli strain KTa008

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1F406
• Locus tag: L6L70_RS16440
• Protein ID: WP_000539521.1
• Coordinates: 3374162..3374548 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: L6L70_RS16445
• Protein ID: WP_001280945.1
• Coordinates: 3374538..3374867 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6L70_RS16420 (3370166)	3370166..3370792	+	627	WP_001295292.1	glutathione S-transferase GstB	-
L6L70_RS16425 (3370789)	3370789..3371904	-	1116	WP_000555051.1	aldose sugar dehydrogenase YliI	-
L6L70_RS16430 (3372015)	3372015..3372398	-	384	WP_000497137.1	biofilm formation regulator BssR	-
L6L70_RS16435 (3372611)	3372611..3373936	+	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
L6L70_RS16440 (3374162)	3374162..3374548	+	387	WP_000539521.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L6L70_RS16445 (3374538)	3374538..3374867	+	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
L6L70_RS16450 (3374937)	3374937..3376265	-	1329	WP_001550887.1	GGDEF domain-containing protein	-
L6L70_RS16455 (3376273)	3376273..3378621	-	2349	WP_001550886.1	EAL domain-containing protein	-
L6L70_RS16460 (3378799)	3378799..3379710	-	912	WP_001236042.1	glutathione ABC transporter permease GsiD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14293.45 Da
• Isoelectric Point: 9.9296

>T234244 WP_000539521.1 NZ_CP091651:3374162-3374548 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T234244 NZ_LR027878:c942433-942245 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT234244 WP_001280945.1 NZ_CP091651:3374538-3374867 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT234244 NZ_LR027878:c942722-942462 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Toxin

• AlphaFold DB: A0A829GCT6