Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3998145..3998661 Replicon chromosome
Accession NZ_CP091640
Organism Salmonella enterica strain 965

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag L5503_RS19125 Protein ID WP_133323120.1
Coordinates 3998145..3998429 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag L5503_RS19130 Protein ID WP_000212724.1
Coordinates 3998419..3998661 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5503_RS19110 (3993357) 3993357..3995009 + 1653 WP_023137597.1 alpha,alpha-phosphotrehalase -
L5503_RS19115 (3995418) 3995418..3997556 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
L5503_RS19120 (3997677) 3997677..3998141 + 465 WP_133323118.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L5503_RS19125 (3998145) 3998145..3998429 - 285 WP_133323120.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L5503_RS19130 (3998419) 3998419..3998661 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L5503_RS19135 (3998739) 3998739..4000652 - 1914 WP_001212140.1 BglG family transcription antiterminator -
L5503_RS19140 (4000669) 4000669..4001409 - 741 WP_023229489.1 KDGP aldolase family protein -
L5503_RS19145 (4001406) 4001406..4002524 - 1119 WP_133323122.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
L5503_RS19150 (4002508) 4002508..4003641 - 1134 WP_133323124.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10926.73 Da        Isoelectric Point: 9.8739

>T234190 WP_133323120.1 NZ_CP091640:c3998429-3998145 [Salmonella enterica]
MTYELEFDPRALKEWHKLDDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T234190 NZ_LR027870:1919774-1919869 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT234190 WP_000212724.1 NZ_CP091640:c3998661-3998419 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT234190 NZ_LR027870:c1919956-1919897 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References