Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3305168..3305788 Replicon chromosome
Accession NZ_CP091640
Organism Salmonella enterica strain 965

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag L5503_RS15950 Protein ID WP_001280991.1
Coordinates 3305570..3305788 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag L5503_RS15945 Protein ID WP_000344807.1
Coordinates 3305168..3305542 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5503_RS15935 (3300307) 3300307..3301500 + 1194 WP_126524221.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L5503_RS15940 (3301523) 3301523..3304672 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
L5503_RS15945 (3305168) 3305168..3305542 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
L5503_RS15950 (3305570) 3305570..3305788 + 219 WP_001280991.1 HHA domain-containing protein Toxin
L5503_RS15955 (3305967) 3305967..3306518 + 552 WP_001278793.1 maltose O-acetyltransferase -
L5503_RS15960 (3306634) 3306634..3307104 + 471 WP_000136183.1 YlaC family protein -
L5503_RS15965 (3307160) 3307160..3307300 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
L5503_RS15970 (3307306) 3307306..3307566 - 261 WP_115276046.1 type B 50S ribosomal protein L31 -
L5503_RS15975 (3307791) 3307791..3309341 + 1551 WP_000213138.1 EAL domain-containing protein -
L5503_RS15985 (3309572) 3309572..3309961 + 390 WP_000961285.1 MGMT family protein -
L5503_RS15990 (3309994) 3309994..3310563 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T234186 WP_001280991.1 NZ_CP091640:3305570-3305788 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T234186 NZ_LR027869:c2634083-2633817 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT234186 WP_000344807.1 NZ_CP091640:3305168-3305542 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT234186 NZ_LR027869:c2634340-2634083 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References