Detailed information of TA system TA234112

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4004229..4004745
• Replicon: chromosome
• Accession: NZ_CP091626
• Organism: Salmonella enterica strain 1165

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: L5507_RS19145
• Protein ID: WP_133323120.1
• Coordinates: 4004229..4004513 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V7ISI8
• Locus tag: L5507_RS19150
• Protein ID: WP_000212724.1
• Coordinates: 4004503..4004745 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5507_RS19130 (3999441)	3999441..4001093	+	1653	WP_023137597.1	alpha,alpha-phosphotrehalase	-
L5507_RS19135 (4001502)	4001502..4003640	+	2139	WP_000187818.1	anaerobic ribonucleoside-triphosphate reductase	-
L5507_RS19140 (4003761)	4003761..4004225	+	465	WP_133323118.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
L5507_RS19145 (4004229)	4004229..4004513	-	285	WP_133323120.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L5507_RS19150 (4004503)	4004503..4004745	-	243	WP_000212724.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
L5507_RS19155 (4004823)	4004823..4006736	-	1914	WP_001212140.1	BglG family transcription antiterminator	-
L5507_RS19160 (4006753)	4006753..4007493	-	741	WP_023229489.1	KDGP aldolase family protein	-
L5507_RS19165 (4007490)	4007490..4008608	-	1119	WP_133323122.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
L5507_RS19170 (4008592)	4008592..4009725	-	1134	WP_133323124.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10926.73 Da
• Isoelectric Point: 9.8739

>T234112 WP_133323120.1 NZ_CP091626:c4004513-4004229 [Salmonella enterica]
MTYELEFDPRALKEWHKLDDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T234112 NZ_LR027516:c652831-652418 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.34 Da
• Isoelectric Point: 5.0651

>AT234112 WP_000212724.1 NZ_CP091626:c4004745-4004503 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT234112 NZ_LR027516:c653094-652828 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A5H5JRI5