Detailed information of TA system TA234071

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3510086..3510478
• Replicon: chromosome
• Accession: NZ_CP091622
• Organism: Salmonella enterica strain 1419

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V9S8T1
• Locus tag: L5509_RS16960
• Protein ID: WP_000994223.1
• Coordinates: 3510233..3510478 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3510086..3510442 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5509_RS16930	3505338..3505835	-	498	WP_165963407.1	pilus assembly protein	-
L5509_RS16935	3506597..3507301	-	705	Protein_3314	integrase core domain-containing protein	-
L5509_RS16940	3507354..3507668	+	315	WP_133322996.1	SymE family type I addiction module toxin	-
L5509_RS16945	3507735..3508013	-	279	WP_133323248.1	hypothetical protein	-
L5509_RS16950	3508331..3508798	-	468	WP_000828178.1	sugar tyrosine-protein kinase	-
L5509_RS16955	3509616..3510035	-	420	WP_131040133.1	hypothetical protein	-
-	3510086..3510442	-	357	-	-	Antitoxin
L5509_RS16960	3510233..3510478	+	246	WP_000994223.1	hypothetical protein	Toxin
L5509_RS16965	3510545..3511087	-	543	WP_079984650.1	hypothetical protein	-
L5509_RS16970	3511087..3515193	-	4107	WP_133322998.1	RHS repeat-associated core domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3497433..3511087	13654

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8789.96 Da
• Isoelectric Point: 4.1428

>T234071 WP_000994223.1 NZ_CP091622:3510233-3510478 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYQAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

>T234071 NZ_LR025099:c1300241-1300023 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Nucleotide

• Length: 357 bp

>AT234071 NZ_CP091622:c3510442-3510086 [Salmonella enterica]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCATCGCGCCTCTCTCTCCCCG
GCCAGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V9S8T1

Antitoxin