Detailed information of TA system TA234033

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4497466..4498220
• Replicon: chromosome
• Accession: NZ_CP091615
• Organism: Salmonella enterica strain 1653

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: L5511_RS21530
• Protein ID: WP_133323219.1
• Coordinates: 4497466..4497777 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L5511_RS21535
• Protein ID: WP_001259009.1
• Coordinates: 4497774..4498220 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5511_RS21500 (4493124)	4493124..4494026	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
L5511_RS21505 (4494023)	4494023..4494658	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L5511_RS21510 (4494655)	4494655..4495584	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L5511_RS21515 (4495631)	4495631..4495921	-	291	WP_000362050.1	DNA-binding transcriptional regulator	-
L5511_RS21520 (4495922)	4495922..4496233	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	-
L5511_RS21525 (4496451)	4496451..4497380	+	930	WP_001127694.1	alpha/beta hydrolase	-
L5511_RS21530 (4497466)	4497466..4497777	+	312	WP_133323219.1	type II toxin-antitoxin system HigB family toxin	Toxin
L5511_RS21535 (4497774)	4497774..4498220	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
L5511_RS21540 (4498235)	4498235..4499176	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L5511_RS21545 (4499221)	4499221..4499658	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
L5511_RS21550 (4499655)	4499655..4500527	-	873	WP_000921423.1	virulence factor BrkB family protein	-
L5511_RS21555 (4500521)	4500521..4501120	-	600	WP_000965698.1	glucose-1-phosphatase	-
L5511_RS21560 (4501311)	4501311..4502114	-	804	WP_000059693.1	DeoR/GlpR family DNA-binding transcription regulator	-
L5511_RS21565 (4502148)	4502148..4503044	-	897	WP_001520529.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12490.44 Da
• Isoelectric Point: 9.1995

>T234033 WP_133323219.1 NZ_CP091615:4497466-4497777 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSDNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Nucleotide

• Length: 312 bp

>T234033 NZ_LR025089:c215005-214589 [Klebsiella pneumoniae]
ATGACCAAAACCTACATGCTGGATACTAATATCTGCTCTTATATCATGCGCGAACAACCGGAAGCGGTGCTGAAACGCCT
AGAGCAAGCGGTGTTGCGCCGTCACCGGATAGTGGTGTCAGCCATCACCTATGCCGAAATGCGTTTTGGTGCCATCGGTA
AAAGGGCTTCGCCCCGTCATGTGCAGCTGGTGGACGCATTCTGTGCGCGCCTTGATGCCATACTGGCTTGGGATCGGGCC
GCAGTTGACGCTACAACAGAGGTTAAGGCCACGCTAGCAGCTGCCGGCACGCCAATCGGCCCAAACGACACAGCCATTGC
TGGACATGCCATTGCCGCTGGCGCCATCCTGGTGACGAATAATACGCGTGAATTTGAGCGAGTCGCTGGTCTGACGTTTG
AAGACTGGGTGCAATAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16720.06 Da
• Isoelectric Point: 6.6451

>AT234033 WP_001259009.1 NZ_CP091615:4497774-4498220 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT234033 NZ_LR025089:c215232-215002 [Klebsiella pneumoniae]
ATGCGAACTGTATCTGTATTCAGGAACGGTAATAACCGGGCCATCCGTCTGCCCCGCGATCTGGACTTTGACGGCGTGAA
CGAACTGGAAATCATCCGCGAGGGCGATACCCTCATCCTGCGGCCGGTAAAACCCAGTTGGAGTTCGTTCCGCCAGGAGG
AAAAAGCTGACGCAGATTTTATGGCGGAGCGTGAAAATGTTGTTAGTGACGAGGGACGTTTTGAGCTATGA