Detailed information of TA system TA234032

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4495631..4496233
• Replicon: chromosome
• Accession: NZ_CP091615
• Organism: Salmonella enterica strain 1653

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: L5511_RS21520
• Protein ID: WP_001159630.1
• Coordinates: 4495922..4496233 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L5511_RS21515
• Protein ID: WP_000362050.1
• Coordinates: 4495631..4495921 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5511_RS21500 (4493124)	4493124..4494026	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
L5511_RS21505 (4494023)	4494023..4494658	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L5511_RS21510 (4494655)	4494655..4495584	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L5511_RS21515 (4495631)	4495631..4495921	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
L5511_RS21520 (4495922)	4495922..4496233	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
L5511_RS21525 (4496451)	4496451..4497380	+	930	WP_001127694.1	alpha/beta hydrolase	-
L5511_RS21530 (4497466)	4497466..4497777	+	312	WP_133323219.1	type II toxin-antitoxin system HigB family toxin	-
L5511_RS21535 (4497774)	4497774..4498220	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
L5511_RS21540 (4498235)	4498235..4499176	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L5511_RS21545 (4499221)	4499221..4499658	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
L5511_RS21550 (4499655)	4499655..4500527	-	873	WP_000921423.1	virulence factor BrkB family protein	-
L5511_RS21555 (4500521)	4500521..4501120	-	600	WP_000965698.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T234032 WP_001159630.1 NZ_CP091615:c4496233-4495922 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T234032 NZ_LR025089:c140452-139970 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT234032 WP_000362050.1 NZ_CP091615:c4495921-4495631 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT234032 NZ_LR025089:c140706-140440 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64