Detailed information of TA system TA234031

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4042990..4043506
• Replicon: chromosome
• Accession: NZ_CP091615
• Organism: Salmonella enterica strain 1653

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: L5511_RS19410
• Protein ID: WP_133323120.1
• Coordinates: 4042990..4043274 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V7ISI8
• Locus tag: L5511_RS19415
• Protein ID: WP_000212724.1
• Coordinates: 4043264..4043506 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5511_RS19395 (4038202)	4038202..4039854	+	1653	WP_023137597.1	alpha,alpha-phosphotrehalase	-
L5511_RS19400 (4040263)	4040263..4042401	+	2139	WP_000187818.1	anaerobic ribonucleoside-triphosphate reductase	-
L5511_RS19405 (4042522)	4042522..4042986	+	465	WP_133323118.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
L5511_RS19410 (4042990)	4042990..4043274	-	285	WP_133323120.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L5511_RS19415 (4043264)	4043264..4043506	-	243	WP_000212724.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
L5511_RS19420 (4043584)	4043584..4045497	-	1914	WP_001212140.1	BglG family transcription antiterminator	-
L5511_RS19425 (4045514)	4045514..4046254	-	741	WP_023229489.1	KDGP aldolase family protein	-
L5511_RS19430 (4046251)	4046251..4047369	-	1119	WP_133323122.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
L5511_RS19435 (4047353)	4047353..4048486	-	1134	WP_133323124.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10926.73 Da
• Isoelectric Point: 9.8739

>T234031 WP_133323120.1 NZ_CP091615:c4043274-4042990 [Salmonella enterica]
MTYELEFDPRALKEWHKLDDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T234031 NZ_LR025089:c18700-18209 [Klebsiella pneumoniae]
GTGGGCAAAGTAACGGCTCCGGTCCCACTCGGTACGTCACACATCCTCGCTGAGTTTCACTGTGGTGAGCCTGTACTGGA
CGAATGGATAAAGCACCGGGGACTAAAAAATCAGTCCCTGGGGGCGGCCAGAACGTTTGTGGTGTGCCGGGGAAATGCTT
CACAGGTGCTTGCCTACTACTCTCTCGCGACCGGCAGCGTCACTCATGCCATTGCGCCGGGAAGCCTGCGAAGGAATATG
CCCGATCCTGTACCTGTCATCATCCTGGCCCGTCTTGCTGTCGATACGAGTTATCACGGCCAGGGACTGGGGGCTGATTT
ACTGCATGATGCCGTATTACGTTGCTGTCGGGTGGCTGAGAACATTGGCGTGCGGGCCGTTATGGTTCATGCACTCTCTG
ACAGTGCCAGACAGTTCTACATACATCACGGATTTATCCCTTCACAAACGCAGGATAGAACCCTTTTTTTACGGTTGCCT
CTCATTACTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.34 Da
• Isoelectric Point: 5.0651

>AT234031 WP_000212724.1 NZ_CP091615:c4043506-4043264 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT234031 NZ_LR025089:c18954-18688 [Klebsiella pneumoniae]
ATGAAATCTGATGTTCAGCTCAACATCCGGGCGAAAGAAGCCCAGCGGGCTCTGATTGATACTGCCGCTGAGATTCTCCA
CAAATCACGCACTGATTTTATACTGGAGATGGCCTGTCAGGCGGCGGAAAACGTCATTCTTGACCGCCGTATGTTCAATC
TCAATGATGAACAGTACGCCGAGTTTATCGACATGCTGGATGCGCCGGTCACCGCTAACCCGGCGATGGAGAAACTCCTG
GCGAGAAAACCGCAGTGGGCAAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A5H5JRI5