Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 62333..62858 Replicon plasmid pR85_2-2
Accession NZ_CP091585
Organism Klebsiella pneumoniae strain Nord9_R85

Toxin (Protein)


Gene name ccdB Uniprot ID A0A6S4YF27
Locus tag L5468_RS29100 Protein ID WP_025714517.1
Coordinates 62333..62638 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID W8V2V6
Locus tag L5468_RS29105 Protein ID WP_001568025.1
Coordinates 62640..62858 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5468_RS29070 (L5468_29075) 57996..58622 + 627 WP_004197649.1 ParA family plasmid-partitioning AAA ATPase -
L5468_RS29075 (L5468_29080) 58619..58921 + 303 WP_071571079.1 hypothetical protein -
L5468_RS29080 (L5468_29085) 59409..60203 - 795 WP_004197635.1 site-specific integrase -
L5468_RS29085 (L5468_29090) 60401..61417 - 1017 WP_017899884.1 hypothetical protein -
L5468_RS29090 (L5468_29095) 61428..61742 - 315 WP_053389906.1 hypothetical protein -
L5468_RS29095 (L5468_29100) 61769..62164 - 396 WP_017899885.1 hypothetical protein -
L5468_RS29100 (L5468_29105) 62333..62638 - 306 WP_025714517.1 type II toxin-antitoxin system toxin CcdB Toxin
L5468_RS29105 (L5468_29110) 62640..62858 - 219 WP_001568025.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
L5468_RS29110 (L5468_29115) 63438..64007 + 570 WP_016162066.1 hypothetical protein -
L5468_RS29115 (L5468_29120) 64148..65176 + 1029 WP_001568023.1 Abi family protein -
L5468_RS29120 (L5468_29125) 65321..65752 - 432 WP_237437282.1 hypothetical protein -
L5468_RS29125 (L5468_29130) 65969..67137 + 1169 WP_237437283.1 IS3-like element ISEc52 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..124386 124386


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11562.25 Da        Isoelectric Point: 5.6906

>T233913 WP_025714517.1 NZ_CP091585:c62638-62333 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSCELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T233913 NZ_LN854557:c3452377-3451970 [Sodalis glossinidius str. 'morsitans']
GTGGCCCTTTGGCGATGTGATATCCGGGTCTCCTGGCGCACTCAGCTTTGCTCGCTGGCGTTTTACGGGATCCTGATTAT
GCTGATTTTACTCTCGCCCTGGCCGGAAAATTACGGACTGGTGTGGTTGACGCTGGTACTGGTGGTGGTGTTTGAATGCA
TCCGCAGCCAGCGCAACATCATGTCGTGCCGCGGCGAGCTAGTGTTAATGAGCGACAACAGTATTCAATGGCATCGTGAG
GAGTGGATCTTCACCCGCAAAGCCTGTATGCTCAAGGGCGGTGCGGTGCTCAGCCTGCGCAAAGTGGGCGGCAAACGGCG
CCGGCGGTTATGGTTGGCGGCGGACAGCATGGACGGCCGGGAATTTCGCCACCTGCGCCAGCTGCTGGCGCGCCAGGCCG
GGTCCTAG

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8392.34 Da        Isoelectric Point: 4.7405

>AT233913 WP_001568025.1 NZ_CP091585:c62858-62640 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT233913 NZ_LN854557:c3452624-3452358 [Sodalis glossinidius str. 'morsitans']
ATGGATATCACCAACAAAGCGCGGATCCACTGGGCCTGCCGCCGTGGCATGCGCGAGCTGGATATCGCCATTATGCCGTT
CTTTGAACACGATTTTGACGCCCTGGATGACCAGGACAAACAACGCTTTGTCCGGCTGCTGGAGTGCGACGATCCCGATT
TGTTCTATTGGCTGATGAACCACGGCCAGCCGGACGACGGCGAGCTGCGGCAGATTATTACCATGATTCAGACGCGAAAC
AAAGCCCGTGGCCCTTTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6S4YF27

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZZP8

References